Repetitive Transcranial Magnetic Stimulation (rTMS) in Unipolar Depression
试验速览
- 阶段
- 早期 1 期
- 状态
- 已完成
- 入组人数
- 21
- 试验地点
- 2
- 主要终点
- Hamilton Depression Rating Scale
研究概览
简要总结
Repetitive Transcranial Magnetic Stimulation (rTMS) can improve mood and decrease sadness in patients with depression.
In this study, the investigators seek to increase their understanding about how rTMS improves depression, and to determine which form of rTMS is most effective for depression, when used in combination with antidepressant medication.
详细描述
Patients will be assigned for 4 treatment arms, receiving either left high frequency plus right low frequency, or left high frequency plus right sham, or left sham, plus right low frequency, or left sham plus right sham treatment. All subjects will receive treatments for 10 days and will be followed for another 4 weeks.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Major Depression
- •No physical health problems
排除标准
- •History of Epilepsy
- •Metal in the head/neck or skull
- •Pacemaker
- •Pregnancy
结局指标
主要结局
Hamilton Depression Rating Scale
时间窗: Pre TMS and post TMS
Beck Depression Rating Scale
时间窗: pre TMS and post TMS
次要结局
- Quantitive Electroencephalographic(QEEG)activity and measures of regional cerebral blood flow(pre TMS and post TMS as well as post phase II, second set of TMS)