The Effects of Dietary Intake of Cod Residual Material Meal on Lipid Regulation, Glucose Regulation and Body Composition in Physically Active Adults

Not Applicable

Completed

• Conditions: Physical Activity; Healthy
• Interventions: Dietary Supplement: Cod meal from residual material; Dietary Supplement: Control

• Registration Number: NCT03538834
• Lead Sponsor: University of Bergen

Brief Summary

A high intake of fish is associated with positive health effects, including prevention and treatment of chronic non-communicable diseases, such as cardiovascular diseases (CVDs) and type 2 diabetes. These health effects have traditionally been attributed to the omega-3 fatty acids in fatty fish, but recent studies have suggested that also fish proteins may improve biomarkers of metabolic disease. Intake of cod fillet have previously shown beneficial effects on blood lipids, glucose regulation and body composition in adults with overweight or obesity. Health effect of cod residual material from fillet production (i.e., head, backbone, skin, cutoffs and entrails) have so far not been investigated, but residuals from other fish species have shown promising effects on glucose regulation in rats. The main aim of the current study is to investigate the effects of cod residual meal on serum lipids and glucose regulation in healthy, physically active adults.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-01
• Study First Submitted: 2018-05-14
• Study First Submitted QC: 2018-05-24
• Study First Posted: 2018-05-29
• Primary Completion: 2019-12
• Study Completion: 2021-12
• Status Verified: 2022-03
• Last Update Submitted: 2022-03-29
• Last Update Posted: 2022-03-31

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

• BMI ≥ 18.5 kg/m2
• Fasting blood glucose ≤7 mmol/L
• Physically active
• Percent body fat, 5-25 % for men and 12-35 % for women

Exclusion Criteria

• Allergies towards fish, milk, egg, gluten
• Tobacco use > 10 cigarettes (or snus) per day
• Diseases affecting the heart, intestinal function, kidney function or insulin secretion
• Medications targeting cholesterol -or glucose metabolism, hypertension
• Use of dietary supplements
• Pregnancy or lactation

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Cod meal from residual material	Cod meal from residual material	Dietary supplement: cod meal from residual material, 8 g protein daily for 8 weeks
Control	Control	Control group receive tablet containing fillers and no protein

Primary Outcome Measures

Name	Time	Method
Lipid metabolism	8 weeks	Lipids will be measured in fasting serum samples

Secondary Outcome Measures

Name	Time	Method
Biomarkers related to glucose regulation	8 weeks	Glucose, insulin and GLP-1 and will be measured in serum/plasma sampled in fasting and postprandial conditions
Body composition	8 weeks	Percent body fat will be measured using bioimpedance

Trial Locations

Locations (1)

Oddrun Anita Gudbrandsen; 🇳🇴 Bergen, Norway