Concentration of prophylactic intraosseous regional vancomycin administration prior to total knee arthroplasty in the obese patient

Phase 1

• Conditions: Infection following total knee arthroplasty; Surgery - Surgical techniques; Infection - Studies of infection and infectious agents

• Registration Number: ACTRN12614001297617
• Lead Sponsor: Seung Joon Chin

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2014-12-11
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 22

Inclusion Criteria

Undergoing primary total knee replacement
Informed consent given
Age>55
Age<85
BMI greater than or equal to 35

Exclusion Criteria

Previous compartment syndrome
Allergy to antibiotics used in the study
Abnormal cardiac, renal or liver function
Concurrent nephrotoxic medications
BMI <35

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Fat and bone concentration of vancomycin from seven tissue samples. Four fat samples and three bone samples.[At 4 time points intraoperatively.<br>Post incision<br>Distal femoral cut<br>Component trialling<br>Prior to closure]