Differences in unaffected skin of patients with hidradenitis suppurativa compared with healthy controls.

Conditions: Acne inversa
Verneuil's disease
10003816
10040798

Registration Number: NL-OMON49510

Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Not specified

Target Recruitment: 20

Inclusion Criteria

In order to be eligible to participate in this study, HS patients must meet all
of the following criteria:
- Adults (* 18 years old) suffering from HS
- Competent and willing to provide informed consent.

In order to be eligible to participate in this study, healthy controls must
meet all of the following criteria:
- Adults (* 18 years old) not suffering from HS
- Competent and willing to provide informed consent.

Exclusion Criteria

Exclusion criteria for HS patients:
- Use of systemic or local antibiotics in the axillae or groin in the past 2
weeks
- Use of any other medication potentially affecting the immune system or
microbiome

Exclusion criteria for healthy controls:
- <18 years of age
- Presence of any inflammatory (skin) disease
- Positive family history of HS
- Use of systemic or local antibiotics in the axillae or groin in the past 2
weeks
- Use of any other medication potentially affecting the immune system

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary outcome:<br /><br>The difference in gene expression profile of unaffected skin from the axillae<br /><br>or groins of HS patients and healthy controls.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary outcomes:<br /><br>1. Microbial differences in uninvolved skin of HS axillae or groins and that of<br /><br>healthy controls.<br /><br>2. Histological and immunohistochemical differences in uninvolved skin of HS<br /><br>axillae or groins and that of healthy controls</p><br>