NCT04081285已完成不适用
Identification of Epigenetic Biomarkers for Alzheimer's Disease in Blood Using Epigenome-wide Analysis
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 250
- 试验地点
- 1
- 主要终点
- DNA methylation
研究概览
简要总结
Alzheimer's disease (AD) is a neurodegenerative disorder with no know cure. The pathogenesis of late onset AD (LOAD) is complex and multifactorial in nature, with multiple susceptibility genes and environmental factors at interplay.
The objective of this study is to improve our understanding of the risk factors of LOAD by conducting an epigenome wide study within patients of LOAD contrasted against their cognitively normal siblings.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 50 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Sufficient Cantonese competency for cognitive test
- •Written informed consent given
- •Have at least one gender-matched cognitively normal sibling
排除标准
- •Subjects who refuse blood taking procedure
- •Do not have a reliable family/caregiver informant (personal contact at least once a month)
结局指标
主要结局
DNA methylation
时间窗: 5 years
RNA-seq microbiome
时间窗: 5 years
Alzheimer's disease Assessment Scale-cognitive subscale (Adas-Cog)
时间窗: 5 years
次要结局
未报告次要终点
研究者
Timothy Kwok
Professor
Chinese University of Hong Kong
研究点 (1)
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