Effects of Omega-3 and Whey Protein Supplementation on Lean Mass and Strength Gains in Older Adults Performing Resistance Exercise: A Randomized, Double-Blind and Placebo-Controlled Study
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 75
- 试验地点
- 2
- 主要终点
- Changes in lean mass (kg) using ultrasound and dual-energy X-ray absorptiometry (DXA) in postmenopausal women
研究概览
简要总结
To evaluate the effect of omega-3 supplementation combined with whey protein intake on lean mass, muscle strength, metabolomic and lipidomic profiles, and biomarkers of oxidative stress and inflammation in older adults undergoing resistance exercise. Participants will be randomized into the 4 groups. The placebo group will receive 5 g per day of sunflower oil and 38 g per day of maltodextrin. The omega 3 + placebo group will receive 5 g per day of fish oil and 38 g per day of maltodextrin. The whey protein + placebo group will receive 38g per day of whey and 5g per day of sunflower oil. The omega 3 + whey group will receive 5g per day of fish oil and 38g per day of protein. All will perform the same exercise protocol for 12 weeks.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 60 Years 至 80 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Postmenopausal women (at least 1 year of menstrual interruption, self-reported);
- •To be able to practice strength exercises;
- •To be able to carry out supplementation;
- •Do not present physical, orthopedic or cardiovascular complications that prevent the performance of physical exercises;
- •No history of stroke or acute myocardial infarction;
- •Not being a smoker and/or alcoholic;
- •Do not perform hormone replacement therapy;
- •Do not use anti-inflammatory drugs;
- •To have normal kidney function;
- •To submit a medical certificate of health that proves that the individual is able to perform exercises.
排除标准
- •Do not provide the necessary information for the development of the study;
- •Individuals with diseases previously diagnosed and undergoing treatment, such as type II diabetes mellitus, cancer, rheumatoid arthritis, cardiovascular, and kidney and/or liver diseases.
研究组 & 干预措施
Whey Protein + Placebo
Group supplemented with isolated whey protein (38g/day) and sunflower oil (5g/day). All groups will undergo a training program with strength exercises for 12 weeks.
干预措施: Whey Protein + Placebo (Dietary Supplement)
Omega 3 + Placebo
Group supplemented with omega-3 (5g/day) and maltodextrin (38g/day). All groups will undergo a training program with strength exercises for 12 weeks.
干预措施: Omega 3 + Placebo (Dietary Supplement)
Omega 3 + Whey Protein
Group supplemented with omega-3 (5g/day) and whey protein (38g/day). All groups will undergo a training program with strength exercises for 12 weeks.
干预措施: Omega 3 + Whey Protein (Dietary Supplement)
Placebo Group
Group supplemented with maltodextrin (38g/day) and sunflower oil (5g/day). All groups will undergo a training program with strength exercises for 12 weeks
干预措施: Placebo Group (Dietary Supplement)
结局指标
主要结局
Changes in lean mass (kg) using ultrasound and dual-energy X-ray absorptiometry (DXA) in postmenopausal women
时间窗: up to 12 weeks
Changes in lean mass (kg) using ultrasound and electrical bioimpedance in postmenopausal women
时间窗: up to 12 weeks
次要结局
- Changes in strength (kg) using dynamometer in postmenopausal women(up to 12 weeks)
研究者
Erick Prado de Oliveira
Assistant professor
Federal University of Uberlandia