Intracranial Rescue Stenting for Acute Ischemic Stroke, Predictors of Outcomes
试验速览
- 阶段
- 不适用
- 入组人数
- 25
- 主要终点
- number of participants with good re-perfusion after successful rescue stenting
研究概览
简要总结
The use of rescue intracranial stenting is thought to be associated with better outcomes than with patients received medical treatment only after failed thrombectomy as Reperfusion technique. This raised the questions about the factors that affect outcomes of rescue intracranial stenting angioplasty, so the best outcomes can be achieved.
详细描述
Mechanical Thrombectomy is the first line therapy in acute ischemic stroke due to large vessel occlusion. Recently, there is an increasing number of patients with failed re perfusion after mechanical thrombectomy, due to preexisting high degree of intracranial stenosis or failed mechanical thrombectomy. This is associated with poor clinical and functional outcome for the patients.
The percentage of patients with failed mechanical thrombectomy is as high as 40-45% of all patients with ischemic stroke due to large vessel occlusion.
This group is in need for rescue intracranial stenting to achieve re-canalization of the occluded vessel and restore perfusion.
The results demonstrated superiority of medical management over stenting with less complications and this had almost put the intracranial stenting to rest for years.
The main complication related to rescue stenting are ischemic complications especially thromboembolic events related to thrombus detachment, symptomatic intracerebral hemorrhage and re-stenosis of cerebral arteries after stenting.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with acute ischemic stroke due to large vessel occlusion as confirmed by CT angiography or Magnetic resonance (MR) angiography.
- •Baseline NIHSS >
- •Presenting within the first 6 hours from onset of symptoms.
- •First ever stroke or pre-stroke modified Rankin Score (mRS) ≤1.
排除标准
- •Patients with intra cranial hemorrhage.
- •Patients younger than 18 years.
- •Patients with acute ischemic stroke due to small vessel disease or vasculitis.
- •Patients with acute ischemic stroke due to occlusion of vessels of posterior circulation.
- •Patients who refused to be included in the study.
- •Patients with contraindications to intracranial stent placement (as total occlusion of artery).
结局指标
主要结局
number of participants with good re-perfusion after successful rescue stenting
时间窗: 12 months
this may help in case selection for best outcomes of the procedure
次要结局
- Compare the clinical outcomes of participants with rescue stenting with those who received medical treatment.(12 months)
- Compare the radio-logical outcomes of participants with rescue stenting with those who received medical treatment.(12 months)
研究者
Mostafa Mohammed Hamdy Ghazally
Assistant lecturer
Assiut University