Effect of transcranial magnetic stimulation in post stroke spasticity in acute stroke

Not Applicable

• Conditions: Health Condition 1: G988- Other disorders of nervous system

• Registration Number: CTRI/2024/01/061225
• Lead Sponsor: AIIMS Bhubaneswar

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 January 2024

Recruitment & Eligibility

• Status: ot Yet Recruiting
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

1. First-time stroke

2. Stroke with in 7 to 30days

3. 18 years of age or older

4. Gender- either male or female

5. Ability to follow three-step directions

6. patients with no spasticity or minimal spasticity

7. Sufficient ambulation or wheelchair mobility to allow subject to present to treatment and testing areas with minimum assist

Exclusion Criteria

1. History of seizure within the past two years

2. Inability to follow three-step directions

3. Anosognosia

4. Moderate to severe receptive aphasia

5. Premorbid spasticity or neurologic impairment prior to stroke

6. Co-morbidities impairing upper extremity function such as fracture or deformity

7. Indwelling metal or medical devices incompatible with TMS

8. Pregnancy

9. Bi-hemispheric or multifocal stroke

10. Severe dementia

11. Neurolytic injection within the 3 months prior to onset of study or planned neurolytic injection during

study period

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in Baseline modified Modified Ashworth Scale score from Day 1 (Pre-treatment) to Day 5 <br/ ><br>(Post-treatment),at 1monthTimepoint: Change in modified Modified Ashworth Scale score at baseline,at 4weeks and 12weeks.

Secondary Outcome Measures

Name	Time	Method
1.Motor function improvement will be assessed through digital hand dynamometer. <br/ ><br>2.Change in Baseline Corticospinal Excitability Measures from Day 1 (Pre-treatment) to Day 5 (Post- <br/ ><br>treatment). Corticospinal excitability measures used will include threshold & motor evoked potential <br/ ><br>(MEP) amplitude & cortical silent period duration.Timepoint: at baseline,4weeks & at 12weeks