Effects of a Multimodal Intervention Combining Cranio-Cervicomyofascial Release, Transcutaneous Auricular Vagus Nerve Stimulation, and Exercise on Pain, Oral Function, Oral Health–Related Quality of Life, and Headache in Patients With Temporomandibular Disorders
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Pain intensity
研究概览
简要总结
Temporomandibular disorders (TMD) affect 5–12% of the population and are a leading cause of chronic orofacial pain, impaired jaw function, and reduced oral health–related quality of life (OHRQoL). TMD is often associated with cervicogenic headache, neck dysfunction, and psychosocial distress, making management complex.
Conservative treatments, including manual therapy, exercise, and behavioral interventions, are recommended as first-line care. However, emerging therapies such as cranio-cervicomyofascial release (CCMR) and transcutaneous auricular vagus nerve stimulation (taVNS) show promise for pain modulation, autonomic regulation, and functional recovery.
To date, no study has examined the combined effects of CCMR, taVNS, and exercise as a multimodal intervention for TMD. This study addresses that gap by testing an integrated approach targeting musculoskeletal, neurological, and functional components of TMD.
研究设计
- 研究类型
- Interventional
- 分配方式
- Coin toss, Lottery, toss of dice, shuffling cards etc
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Diagnosed with TMD per TMD criteria.
- •Reported pain for more than 3 months.
- •Willingness to attend all treatment sessions.
排除标准
- •History of major jaw surgery, fractures, or inflammatory joint disease any Neurological disorders contraindicating vagus nerve stimulation and Pregnancy or other medical contraindications.
结局指标
主要结局
Pain intensity
时间窗: Baseline, Post, 3 months
次要结局
- Oral function, OHRQoL, OHRQoL, Headache severity/frequency(Baseline, Post, 3 months)
研究者
Dr Ramesh Chandra Patra
Lovely Professional University Faculty of Applied Medical Sciences