Predictors and Outcomes of In-hospital HFpEF in AMI Patients

• Conditions: Acute Myocardial Infarction; Predictor; Prognosis; Heart Failure With Preserved Ejection Fraction

• Registration Number: NCT03351179
• Lead Sponsor: Xiangjun Yang

Brief Summary

This retrospective observation is to investigate the incidence,clinical outcomes and prognosis of hospitalized heart failure with preserved ejection fraction (HFpEF) in patients with acute myocardial infarction(AMI).

Detailed Description

1. Patients with first AMI undergoing primary percutaneous coronary intervention (PCI) in our hospital since January 2013 were retrospectively evaluated. The enrolled subjects were divided into two groups (AMI patients with HFpEF and AMI patients without HF).

2. The investigator collected the clinical data of participants' demographics (age, sex), previous history,risk factors for AMI (hypertension, hyperlipidemia, diabetes mellitus, smoking and stroke), laboratory biomarkers, echocardiographic measurements, clinical characteristics,medical procedures and treatments, as well as in-hospital complications.

3. Two sub-investigators independently analyzed these data by using SPSS software.

Study Timeline

• Study Start: 2013-01-01
• Study First Submitted: 2017-11-04
• Study First Submitted QC: 2017-11-18
• Study First Posted: 2017-11-22
• Status Verified: 2018-12
• Primary Completion: 2018-12-30
• Study Completion: 2018-12-30
• Last Update Submitted: 2018-12-30
• Last Update Posted: 2019-01-02

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 500

Inclusion Criteria

• First AMI patients undergoing PCI with HFpEF or without HF.

Exclusion Criteria

• First AMI patients with heart failure with reduced ejection fraction.
• First AMI patients with severe inflammatory diseases, valvular heart disease, non-cardiac caused symptoms, serious hepatic and renal failure, congenital cardiomyopathy,or pericardial diseases.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Risk factors of incident in-hospital HFpEF	Outcome measure will be assessed at discharge, and data will be reported through study completion, an average of 1 year.

Secondary Outcome Measures

Name	Time	Method
Clinical prognosis in patients with HFpEF	Outcome measure will be assessed at discharge, and data will be reported through study completion, an average of 1 year.

Trial Locations

Locations (1)

the First Affiliated Hospital of Soochow University; 🇨🇳 Suzhou, Jiangsu, China