Arachidonic Acid Metabolism in Carotid Stenosis Plaque in Diabetic Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 204
- 试验地点
- 1
- 主要终点
- Change in arachidonic acid metabolism of atheromatous plaques from diabetic versus non-diabetic subjects
研究概览
简要总结
Diabetes is associated with an increased risk of cardiovascular complications, as a reflection of the chronic inflammatory status. Monocytes-macrophages in diabetic subjects present impaired arachidonic acid metabolism. Moreover, atheromatous plaques in diabetic subjects seem to be significantly enriched in 2-AA-LPC (2-arachidonoyl-lysophosphatidylcholine) and are more inflammatory and more likely to rupture than are plaques in non-diabetic subjects. We therefore hypothesize that this vulnerability of atheromatous plaques in diabetic subjects could be explained by impaired 2-AA-LPC metabolism within the plaque.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients who have provided explicit consent
- •Patients older than 18 years
- •Patients about to undergo surgery for carotid stenosis
- •Haemoglobin ≥ 7g/dl at the time the sample is taken
- •Respect the maximum volume of blood taken (treatment + research) in 30 days
- •SPECIFIC TO DIABETICS
- •- Patients with type 1 or 2 diabetes diagnosed more than 6 months earlier
排除标准
- •Patients under guardianship
- •Patients without health insurance cover
- •Pregnant or breast-feeding women
研究组 & 干预措施
Diabetics
干预措施: blood samples (Procedure)
Diabetics
干预措施: recover samples of atheromatous plaque (Procedure)
Non-diabetics
干预措施: blood samples (Procedure)
Non-diabetics
干预措施: recover samples of atheromatous plaque (Procedure)
结局指标
主要结局
Change in arachidonic acid metabolism of atheromatous plaques from diabetic versus non-diabetic subjects
时间窗: Baseline
次要结局
未报告次要终点