Molecular Epidemiology and Phylodynamic and Phylogeographic Analysis of Community-associated Methicillin-resistant Staphylococcus Aureus (CA-MRSA) Transmission: An Emergency Department Population Sampling Strategy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 575
- 试验地点
- 1
- 主要终点
- Strain Relatedness Identification Through Phylogenetic Analysis
研究概览
简要总结
Given that the Emergency Department (ED) has become the entry way for large populations of patients into the health care system, a strategy of sampling MRSA isolates in ED populations and merging this information with patient-level data may present a window to hypothesize and investigate CA-MRSA transmission within the community and its impact on hospital-acquired infections.
详细描述
Prospective cross-sectional study involving 500 patients enrolled over a one year period at the UFHealth Shands Hospital's Adult and Pediatric Emergency Department. The collected information will serve as pilot data for a future large comprehensive multi-site study.
Patients will have a wound culture and a nasal swab obtained as part of the study, which will be assessed for MRSA isolates using next-generation whole genome sequencing. The principal investigator or PI designee will also survey participants and review hospital records.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 1 Month 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient or Legally Authorized Representative (LAR) must have voluntarily signed an Institutional Review Board-approved informed consent form before initiation of any study procedures
- •Patient presents with an acute abscess or a non-post-operative skin/soft tissue infection
- •Patient presents through the UFHealth Shands Emergency Department
排除标准
- •Patients who are employed by UFHealth and provide direct patient care
- •Patients who have previously been enrolled in the study
- •Patients who are not suitable for the study in the opinion of the investigator
结局指标
主要结局
Strain Relatedness Identification Through Phylogenetic Analysis
时间窗: 1 Hour
Molecular (spa-typing) and genomic (WGS) relatedness of MRSA strains in isolates in ED populations presenting with SSTIs.
次要结局
- Patient Level Characteristics of Skin and Soft Tissue Infection (SSTI) Presentation(6 Months)
- Strain Transmission Through Analysis of Genetic Clustering(1 year)
- Pediatric and Adult Population Presentation Characteristics in Skin and Soft Tissue Infection (SSTI)(6 Months)