Analysis of CA-MRSA Transmission: An ED Population Sampling Strategy

Completed

• Conditions: Methicillin-Resistant Staphylococcus Aureus
• Interventions: Other: Acute Abscess Group

• Registration Number: NCT02363166
• Lead Sponsor: University of Florida

Brief Summary

Given that the Emergency Department (ED) has become the entry way for large populations of patients into the health care system, a strategy of sampling MRSA isolates in ED populations and merging this information with patient-level data may present a window to hypothesize and investigate CA-MRSA transmission within the community and its impact on hospital-acquired infections.

Detailed Description

Prospective cross-sectional study involving 500 patients enrolled over a one year period at the UFHealth Shands Hospital's Adult and Pediatric Emergency Department. The collected information will serve as pilot data for a future large comprehensive multi-site study.

Patients will have a wound culture and a nasal swab obtained as part of the study, which will be assessed for MRSA isolates using next-generation whole genome sequencing. The principal investigator or PI designee will also survey participants and review hospital records.

Study Timeline

• Study First Submitted: 2015-02-09
• Study First Submitted QC: 2015-02-09
• Study First Posted: 2015-02-13
• Study Start: 2015-08
• Primary Completion: 2018-04-04
• Study Completion: 2018-04-04
• Status Verified: 2024-08
• Last Update Submitted: 2024-08-19
• Last Update Posted: 2024-08-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 575

Inclusion Criteria

• Patient or Legally Authorized Representative (LAR) must have voluntarily signed an Institutional Review Board-approved informed consent form before initiation of any study procedures
• Patient presents with an acute abscess or a non-post-operative skin/soft tissue infection
• Patient presents through the UFHealth Shands Emergency Department

Read More

Exclusion Criteria

• Patients who are employed by UFHealth and provide direct patient care
• Patients who have previously been enrolled in the study
• Patients who are not suitable for the study in the opinion of the investigator

Read More

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Acute Abscess Group	Acute Abscess Group	Adults and pediatric patients presenting to the UFHealth Shands Emergency Department with evidence of an acute abscess, or skin/soft tissue infection, which can be sampled for culture and sensitivity testing will be recruited.

Primary Outcome Measures

Name	Time	Method
Strain Relatedness Identification Through Phylogenetic Analysis	1 Hour	Molecular (spa-typing) and genomic (WGS) relatedness of MRSA strains in isolates in ED populations presenting with SSTIs.

Secondary Outcome Measures

Name	Time	Method
Patient Level Characteristics of Skin and Soft Tissue Infection (SSTI) Presentation	6 Months	To determine patient-level characteristics, including social and medical history, associated with a presentation related to SSTIs.
Strain Transmission Through Analysis of Genetic Clustering	1 year	Phlyodynamic analysis of MRSA transmission course by strain
Pediatric and Adult Population Presentation Characteristics in Skin and Soft Tissue Infection (SSTI)	6 Months	Compare patient-level characteristics and phylogenetic clustering between pediatric and adult patients presenting with SSTIs.

Trial Locations

Locations (1)

UF Health; 🇺🇸 Gainesville, Florida, United States