Contact Investigation for Latent Tuberculosis Infection in Healthcare Workers: Exploring Adverse Events Correlation with NAT2 Genotype

Completed

• Conditions: Healthcare workers at Vajira Hospital diagnosed with LTBI who have had close contact with patients diagnosed with pulmonary tuberculosis during the past 3 months and have undergone treatment with the 3HP regimen; Healthcare workers, Latent tuberculosis infection, Tuberculosis preventive therapy, NAT2 genotype

• Registration Number: TCTR20240609004
• Lead Sponsor: /A

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2023-12-31
• Study Start: 2024-06-09
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

Healthcare workers with LTBI at Vajira Hospital who have had significant close contact with patients diagnosed with pulmonary tuberculosis during the 3 months before the index case began treatment, meeting one of the following criteria:
1.Contact with contagious TB for at least 8 hours per day in the same location.
2.Cumulative contact of 120 hours or more per month with contagious TB patients.
3.Exposure to poorly ventilated areas where contagious tuberculosis patients were present and where adequate personal protective equipment (PPE) was not used

Exclusion Criteria

1. HCWs with a history of contact with patients diagnosed with drug-resistant tuberculosis, viral hepatitis infection, human immunodeficiency virus infection, abnormal liver function tests, related to high access alcohol, active cancer on treatment, unstable myocardial ischemia, heart failure grade 3 or 4, other serious illness, potentially serious drug interactions, history of allergic reaction to isoniazid or rifapentine
2. HCWs deny to participate
3. Incomplete data

Study & Design

• Study Type: Observational
• Study Design: Not specified