Phase II Study of Individualized Stereotactic Body Radiotherapy of Liver Metastases
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 92
- 试验地点
- 4
- 主要终点
- Local Control Rate
研究概览
简要总结
Stereotactic body radiation therapy (SBRT) is a technique that is used to deliver radiation, to sites in the body. All participants in this study will be treated with SBRT using proton beam radiation. Proton beam radiation uses tiny particles to deliver radiation to tumors. The purpose of this research study is to determine if SBRT with protons will prevent tumor growth and reduce the treatment side effects for liver metastases.
详细描述
- Participants receiving SBRT with protons, will receive radiation treatment as an outpatient at the Francis H. Burr Proton Therapy Center at Massachusetts General Hospital.
- Not everyone who participates in this study will be receiving the same dose of radiation. The dose received will be determined by the size and location of the tumor(s).
- Participants will receive 2-3 SBRT treatments per week for two weeks.
- During radiation therapy visits the following tests/procedures will be performed: vital signs, physical examination, routine blood tests, research blood tests, and radiation planning.
- Follow-up assessments will be performed once at 9 weeks after study treatment, then at 6 months, 12 months, 18 months and 24 months after treatment.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Biopsy-proven cancer diagnosis of a solid tumor with 1-4 liver metastases. There is no upper size limit. Liver metastases may be diagnosed by imaging alone, no liver biopsy is required. Extrahepatic disease is allowed if it have been stable for 3 months prior to study entry, the dominant disease burden is intrahepatic and the patient is referred for definitive radiation therapy to the disease in the liver
- •Measurable disease, defined as at least one lesion that can be accurately measured in at least one dimension as 10mm or greater with spiral CT scan
- •Patients may have had prior chemotherapy, targeted biological therapy, surgery, transarterial chemoembolization (TACE), radiofrequency ablation, or cryosurgery for their disease as long as the prior therapy occured greater than 3 weeks elapsed before the first radiation treatment. Patients may not have had prior liver directed radiation, including radioembolization.
- •18 years of age or older
- •Expected survival must be greater than three months
- •Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1 or 2
- •Patients must have at least 800mL of uninvolved liver
- •Normal organ and marrow function as outlined in the protocol
- •If patient has underlying cirrhosis, only Child-Pugh classification Group A patients should be included in this study. Clinical assessment of ascites and encephalopathy is required. Child-Pugh classification must be determined for all study participants at the time of eligibility analysis.
- •Women of child-bearing potential and men must agree to use adequate contraception prior to study entry and for the duration of study participation
排除标准
- •Women who are pregnant or lactating
- •Patients with gross ascites or encephalopathy
- •Local conditions or systemic illnesses which would reduce the local tolerance to radiation treatment, such as serious local injuries, active collagen vascular disease, etc.
- •Prior liver directed radiation treatment, including selective internal radiation
- •No serious medical illness, which may limit survival to less than 3 months
- •No serious psychiatric illness which would limit compliance with treatment
- •Participants who have had chemotherapy or radiotherapy within 3 weeks prior to starting study treatment or those who have not recovered from adverse events due to agents administered more than 3 weeks earlier
- •Participants may not be receiving any other investigational agents, or any other anti-cancer therapy during treatment
- •Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia.
- •Only solid tumors are permitted. Thus, individuals with a liver mass from a diagnosis of lymphoma or leukemia are excluded
研究组 & 干预措施
SBRT-Proton
Stereotactic body radiotherapy by proton radiation
干预措施: Stereotactic body radiotherapy-proton (Radiation)
结局指标
主要结局
Local Control Rate
时间窗: 1 year
The percentage of participants with local control at primary tumor site at one year. Local is evaluated using Response Evaluation Criteria In Solid Tumors (RECIST). Local control is defined as achieving either Complete response (CR), Partial Response (PR), or Stable Disease (SD). * (CR): Disappearance of entire lesion, with no additional evidence of disease. * (PR): At least a 30% decrease in the (sum of) the longest diameter (LD) of the primary lesion, taken as reference the baseline sum LD. * (SD): Neither sufficient shrinkage to qualify for PR nor sufficient increase to qualify for PD, taking as reference the smallest sum LD since the treatment started.
次要结局
- Median Overall Survival(2 years)
- 2-year Local Control Rate(2 years)
- Median Progression Free Survival(1 years)
- 1 Year Local Control Rate Among Participants With Colorectal Cancer(1 year)
- Median Follow-up Time(1 year)
- Median Survival Among Participants With Colorectal Cancer(2 years)
研究者
Hannah Roberts
Principal Investigator
Massachusetts General Hospital