Exposure, D-cycloserine Enhancement, and Functional Magnetic Resonance Imaging (fMRI) in Snake Phobics
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Snake Questionnaire (SNAQ)
研究概览
简要总结
The aim of the present study is to determine whether people receiving d-cycloserine and exposure therapy show different brain reactions to symptom provocation compared to people receiving placebo and exposure therapy.
详细描述
D-cycloserine (DCS) is a partial N-methyl-D-aspartate (NMDA) receptor agonist that may improve or accelerate extinction learning. We will randomly assign people with snake phobia to receive DCS or placebo, and then provide all participants with exposure therapy. We will examine whether people receiving DCS and vs. placebo show different brain reactions to symptom provocation before and after exposure therapy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Care Provider, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Primary diagnosis of specific phobia (snakes)
排除标准
- •History of psychosis, obsessive-compulsive disorder, or mania
- •Recent substance abuse or suicidality
- •Previous receipt of study treatments
研究组 & 干预措施
D-cycloserine plus exposure therapy
Single session (up to 3 hr) of in vivo exposure therapy plus 50 mg oral d-cycloserine administered 1 hr prior to exposure therapy session
干预措施: D-cycloserine (Drug)
D-cycloserine plus exposure therapy
Single session (up to 3 hr) of in vivo exposure therapy plus 50 mg oral d-cycloserine administered 1 hr prior to exposure therapy session
干预措施: Exposure therapy (Behavioral)
Placebo plus exposure therapy
Single session (up to 3 hr) of in vivo exposure therapy plus oral placebo capsule administered 1 hr prior to exposure therapy session
干预措施: Exposure therapy (Behavioral)
Placebo plus exposure therapy
Single session (up to 3 hr) of in vivo exposure therapy plus oral placebo capsule administered 1 hr prior to exposure therapy session
干预措施: Placebo (Drug)
结局指标
主要结局
Snake Questionnaire (SNAQ)
时间窗: 2 weeks
30-item self-report scale of severity of snake fear and avoidance Range: 0-30; higher values indicate greater fear severity
次要结局
- Clinician's Global Impression (CGI)-Severity(2 weeks)
- Clinician's Global Impression (CGI)-Improvement(2 weeks)