Evaluation Of Pleural Effusion At Assiut University Hospital
试验速览
- 阶段
- 不适用
- 入组人数
- 1
- 主要终点
- diagnosis new causes of previously remained undiagnosed cases of pleural effusion by using IgG4 in Assiut university hospital
研究概览
简要总结
Pleural effusion is an accumulation of fluid between the tissue layers that line the lungs and chest cavity. It has an estimated prevalence of 320 per 100,000 people in industrialized countries. The cause of the pleural effusion remains unclear in a substantial percentage of patients with persistently exudative effusions.
详细描述
They are classified broadly into exudative and transudative effusion based on Light's criteria.
Several methods have been proposed for the identification of pleural effusion etiology including pleural fluid cytology, pleural biopsy, thoracoscopy and computerized tomography. However, these technologies have their own limitations.
The diagnosis of malignant pleural effusion is a vexing problem, since pleural fluid cytology findings are positive in only 60% of cases on average. Tumor marker carcinoembryonic antigen (CEA) can be positive in 80% of cases.
Thoracoscopy will establish the diagnosis in approximately 95% of cases, but this interventional procedure may not be available at all facilities.
A new approach is needed to detect the cause of undiagnosed pleural effusions. Diagnosis of idiopathic pleural effusion was made after a minimum of one year follow up with detailed exploration including computed tomographic scanning to exclude other causes of effusion such as malignant pleural effusion.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All patients with exudative pleural effusion admitted to Assiut university hospital in period of October 2017 to October 2018
排除标准
- •Patients with transudative pleural effusion
结局指标
主要结局
diagnosis new causes of previously remained undiagnosed cases of pleural effusion by using IgG4 in Assiut university hospital
时间窗: one year
Immunoglobulin G4 will be puified from pleural fluids by diethylaminoetyyl cellulose ion exchange nephlometry in patients with undiagnosed effusion after common investigations as it positive in IgG4 related disease. The median effusion IgG4 level was 41mg/dl in the IgG4 positive group and 27mg/dl in the IgG negative group.
次要结局
未报告次要终点