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Clinical Trials/NCT03770975
NCT03770975
Unknown
Phase 3

Comparison of Peri-implant Soft Tissue Esthetics Around Single Delayed Implant With Immediate Provisionalization Placed in The Esthetic Zone With and Without Using Subepithelial Connective Tissue Graft: A Randomized Clinical Trial

Cairo University1 site in 1 country22 target enrollmentDecember 1, 2018

Overview

Phase
Phase 3
Intervention
Not specified
Conditions
Immediate Temporization and Soft Tissue Augmentation Around Delayed Implants
Sponsor
Cairo University
Enrollment
22
Locations
1
Primary Endpoint
Pink Esthetic Score
Last Updated
7 years ago

Overview

Brief Summary

The aim of this study is to clinically evaluate peri-implant soft tissue esthetics around single delayed implants in the esthetic zone.

Detailed Description

To compare the efficacy of soft tissue augmentation on the peri-implant soft tissue esthetics along with immediate temporization to immediate temporization only. Population (P): patients with a single missing tooth in the esthetic zone Intervention (I): Delayed implant placement with immediate temporization and subepithelial connective tissue graft Comparator (C): Delayed implant placement with immediate temporization Primary outcome: Pink esthetic score (PES) Time frame: 6 months Study design: Randomized controlled clinical trial

Registry
clinicaltrials.gov
Start Date
December 1, 2018
End Date
May 1, 2020
Last Updated
7 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Dina Osama Abdelwahab Megahed

Resident

Cairo University

Eligibility Criteria

Inclusion Criteria

  • Age \> 18 years old
  • Good medical and psychological health
  • Absence of untreated caries lesions and untreated/uncontrolled periodontal disease. If patients required periodontal treatment (non-surgical and/or surgical), this was arranged outside the study protocol and completed at least 30 days prior to the enrolment
  • Need of a single-tooth replacement in the aesthetic (incisor, canine or premolar) region
  • Willingness to sign the informed consent form

Exclusion Criteria

  • Any known disease (not including controlled diabetes mellitus), infections or recent surgical procedures within 30 days of study initiation;
  • Chronic treatment (i.e., 2 weeks or more) with any medication known to affect oral status (e.g., phenytoin, dihydropyridine, calcium antagonists and cyclosporine) within 1 month before baseline visit;
  • Anticoagulant therapy with warfarin, clopidogrel, ticlopidine or once daily aspirin (more than 81 mg);
  • HIV or Hepatitis;
  • Physical handicaps that would interfere with the ability to perform adequate oral hygiene;
  • Alcoholism or chronic drug abuse;
  • Heavy smokers (\>10/cigarettes per day);
  • Lack of adequate primary stability at implant insertion that enables immediate provisionalization (insertion torque ca 30 Ncm).

Outcomes

Primary Outcomes

Pink Esthetic Score

Time Frame: 3 months post definitive prosthesis

Pink esthetic score evaluates the soft tissue esthetics around implant supported crowns. Using a 0-1-2 scoring system, 0 being the lowest, 2 being the highest value. The maximum achievable PES is 14. 7 variables are measured: mesial and distal papillae being 0 if absent, 1 if incomplete and 2 if complete. Alveolar process, soft tissue level, contour, texture and color being 0 if major discrepancy, 1 if minor discrepancy and 2 if matches the contralateral

Secondary Outcomes

  • Buccal peri-implant soft tissue thickness(3 months post definitive)
  • Patient satisfaction by Visual analogue scale (VAS)(3 months post definitive)
  • Recession of the buccal peri-implant mucosa(3 months post definitive)

Study Sites (1)

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