Purines for rapid identification of stroke mimics

Not Applicable

Completed

• Conditions: Stroke; Circulatory System; Stroke, not specified as haemorrhage or infarction

• Registration Number: ISRCTN22323981
• Lead Sponsor: orthumbria Healthcare NHS Foundation Trust

Brief Summary

2021 Protocol article in https://pubmed.ncbi.nlm.nih.gov/34016192/ (added 24/05/2021)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-02-13
• Study Completion: 2021-03-31
• Last Update Posted: 27 December 2021

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 958

Inclusion Criteria

Trained ambulance personnel (paramedics or technicians) responding to an emergency call will attempt a finger prick reading on patients that fulfil the following criteria:

1. Aged 18 years and over
2. At least responsive to strong stimuli during assessment of conscious level (A, V or P on the AVPU scale)
3. Face Arm Speech Test (FAST) positive or any observed new focal neurological symptoms indicating suspected acute stroke in the ambulance personnel's clinical judgement
4. Persistence of the new stroke-like symptoms during the initial clinical assessment
5. Believed to be within 4 hours of the new stroke-like symptoms at the time of the first clinical assessment
6. Will be transported to a study hospital

In order to provide the population to fulfil the objectives of the substudy, trained hospital staff (when available) will attempt a reading on the following subgroup of patients:
1. Had an assay reading attempted by ambulance personnel (whether successful or not)
2. The symptoms resulting in admission are believed to have commenced within 6 hours of the time that the hospital assay can be performed
3. The hospital assay can be performed before intravenous thrombolysis or mechanical thrombectomy if this treatment is indicated

Exclusion Criteria

Exclusion criteria for the ambulance finger prick reading are:
1. Hypoglycaemia (capillary glucose < 3.5mmol/l)
2. External signs of significant acute trauma which are likely to need additional treatment (large haematomas, open wounds, limb deformity)
3. Currently receiving chemotherapy or radiotherapy treatment for cancer

Study & Design

• Study Type: Observational
• Study Design: Not specified