Improving risk stratification for infarction related sudden cardiac death by combining cardiac magnetic resonance imaging, electrocardiographic imaging and epicardial mapping.

Completed

• Conditions: Sudden cardiac death; ventricular arrhythmias; 10007521

• Registration Number: NL-OMON42753
• Lead Sponsor: HagaZiekenhuis

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2017-02-21
• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 11

Inclusion Criteria

CABG group: Patients scheduled for elective coronary artery bypass grafting.
a.Patients without a history of myocardial infarction and ventricular tachyarrhythmias (No-infarct group).
b. Patients with a previous myocardial infarction, but no history of ventricular tachyarrhythmias (No-VT group).
c. Patients with a previous myocardial infarction and a history of ventricular tachyarrhythmias (VT group). ;ICD group: Patients with a prior myocardial infarction, scheduled for ICD implantation.

Exclusion Criteria

- Any contraindication for MRI.
- Pregnant women, or women of child bearing potential and who are not on a reliable form of birth control

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary study parameters include:<br /><br>- 3D electrical activation maps using epicardial mapping and ECGI.<br /><br>- The electrocardiographic characteristics (voltage amplitude, voltage<br /><br>duration, conduction velocity, fractionation) of the different tissue types<br /><br>(e.g. normal myocardium and scar).<br /><br>- The correlation between the electrocardiographic characteristics measured<br /><br>using epicardial mapping and ECGI.<br /><br>- 3D myocardial scar maps.<br /><br>- CMR characteristics of the different tissue types (e.g. normal myocardium and<br /><br>scar).<br /><br>- The correlation between the 3D electrical activation maps obtained using ECGI<br /><br>with the 3D CMR myocardial scar maps.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary study parameters include e.g. individual evaluation of deaths and<br /><br>hospitalizations.</p><br>