Bilateral Knee Strength Asymmetry and Functional Performance in Older Women With Osteoarthritis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Isokinetic Strength Testing
研究概览
简要总结
Osteoarthritis (OA) is a degenerative joint disease that primarily affects the knees and becomes more prevalent with age. In individuals over 50, particularly those with bilateral knee osteoarthritis, it leads to chronic pain, limited mobility, and functional decline. This condition worsens due to muscle strength imbalances, especially in the quadriceps and hamstrings. These imbalances are triggered by pain, joint instability, and cartilage damage, which negatively impact muscle strength and coordination. In women, these asymmetries are more pronounced, increasing the risk of functional decline.
Recent studies highlight the significant role of strength asymmetry in functional limitations, affecting balance, gait, and daily activities. This study aims to investigate the impact of bilateral quadriceps and hamstring strength asymmetries on dynamic balance, gait efficiency, and functional mobility in older women with bilateral knee osteoarthritis.
The study aims to examine the effects of bilateral strength asymmetries in the knee extensors and flexors on dynamic balance, gait efficiency, and overall mobility in older women with bilateral knee osteoarthritis. We hypothesize that greater strength asymmetry will be associated with impaired dynamic balance, reduced gait efficiency, and decreased functional mobility.
详细描述
Osteoarthritis (OA) is a degenerative joint disease that commonly affects the knee, especially in individuals over 50. It leads to pain, reduced mobility, and functional decline. In bilateral knee OA, muscle imbalances, especially in the quadriceps and hamstrings, worsen functional limitations and increase the risk of falls. These imbalances are caused by pain, joint instability, and cartilage damage, affecting muscle strength and coordination. In older women, these issues are more pronounced, increasing their risk of functional decline compared to men.
Emerging research highlights the role of muscle strength asymmetry (differences between the left and right leg) in functional difficulties, such as poor balance, walking issues, and difficulty with daily tasks. This study aims to explore how these muscle imbalances in knee extensors and flexors impact overall functional abilities, such as balance and walking efficiency in women with bilateral knee OA.
The study seeks to examine how bilateral strength asymmetry in the knee muscles affects dynamic balance, gait efficiency, and mobility in older women with knee osteoarthritis. The hypothesis is that greater muscle imbalance will lead to worse balance, slower walking, and reduced mobility.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 50 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •women gender
- •aged 50 years or older
- •diagnosed with bilateral knee osteoarthritis (Kellgren-Lawrence grade II-III),
- •capable of independent walking without assistive devices.
排除标准
- •severe knee osteoarthritis requiring total knee arthroplasty
- •neurological conditions affecting gait or balance
- •severe musculoskeletal disorders
- •uncontrolled systemic diseases
- •cognitive impairments (Mini-Mental State Examination < 24)
结局指标
主要结局
Isokinetic Strength Testing
时间窗: From enrollment to the end of evaluation in 1 hour
Bilateral knee strength asymmetry was assessed using a Biodex System 4 Pro isokinetic dynamometer (Biodex Medical Systems, USA). Participants were securely positioned, and knee extensor and flexor strength were measured at angular velocities of 120°/s and 180°/s. Each participant performed five maximal concentric contractions per limb, with the highest peak torque values recorded. Higher asymmetry values indicated greater strength imbalances between limbs
Functional Mobility
时间窗: From enrollment to the end of evaluation in 1 hour
The 30-second Sit-to-Stand test was used to assess lower limb functional strength and endurance. Participants were instructed to stand up and sit down as many times as possible in 30 seconds from a standard chair (seat height: 46 cm) without using their arms. The total number of completed repetitions was recorded. A lower Sit-to-Stand score indicates reduced quadriceps endurance, decreased functional independence, and a higher fall risk in older adults.
次要结局
- Pain Assessment(From enrollment to the end of evaluation in 1 hour)
- Dynamic Balance Measurement(From enrollment to the end of evaluation in 1 hour)
- Gait Speed(From enrollment to the end of evaluation in 1 hour)
研究者
Sena Çınarlı
Asisstant Professor
Kocaeli Sağlık ve Teknoloji Üniversitesi