Diagnostic Value of D-dimer/Fibrinogen Ratio in Patients With Acute Aortic Dissection

Recruiting

• Conditions: Aortic Dissection; Pulmonary Embolism
• Interventions: Diagnostic Test: D-dimer/fibrinogen ratio

• Registration Number: NCT04251247
• Lead Sponsor: Dr. Lutfi Kirdar Kartal Training and Research Hospital

Brief Summary

Acute aortic dissection is rare but potentially life-threatening disease with an incidence of 5-30 cases per million, annually. Therefore prompt diagnosis is crucial. D-dimer values have been shown to be useful in the diagnosis of acute aortic dissection. Fibrinogen levels have been shown to be low, normal or high in individuals with acute aortic dissection. This study aims to investigate whether D-dimer/fibrinogen ratio can be valuable for diagnosis of acute aortic dissection.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2020-01-30
• Study First Submitted QC: 2020-01-30
• Study First Posted: 2020-01-31
• Study Start: 2020-03-01
• Status Verified: 2024-03
• Last Update Submitted: 2024-03-12
• Last Update Posted: 2024-03-15
• Primary Completion: 2024-12-31
• Study Completion: 2025-01-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 159

Inclusion Criteria

• Diagnosis of acute aortic dissection
• Diagnosis of acute pulmonary embolism
• Diagnosis of non-cardiac chest pain

Exclusion Criteria

• Any etiology of chest pain other than acute aortic dissection, acute pulmonary embolism, or non-cardiac chest pain
• Participants who do not give consent for enrollment

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Acute aortic dissection	D-dimer/fibrinogen ratio	Patients with a diagnosis of acute aortic dissection.
Non-cardiac chest pain	D-dimer/fibrinogen ratio	Patients with non-cardiac chest pain
Acute pulmonary embolism	D-dimer/fibrinogen ratio	Patients with a diagnosis of acute pulmonary embolism

Primary Outcome Measures

Name	Time	Method
Acute aortic dissection	24 hours	Diagnosis of acute aortic dissection confirmed by contrast enhanced computed tomography, magnetic resonance imaging, echocardiography or aortography

Trial Locations

Locations (2)

Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital; 🇹🇷 Istanbul, Turkey

Kartal Dr. Lutfi Kirdar Training and Research Hospital; 🇹🇷 Istanbul, Turkey