Acute Inflammation After Wisdom Tooth Removal
- Conditions
- Tooth Impacted
- Interventions
- Procedure: Wisdom tooth removal
- Registration Number
- NCT03048175
- Lead Sponsor
- University of Pisa
- Brief Summary
Third molar (wisdom teeth) extraction is one of the most frequent intervention in dentistry. Nevertheless, little is known about the level of general body inflammation of subjects with impacted or semi-impacted third molars. Moreover, The possible effects of surgical removal of wisdom teeth on the overall health are not known.
Thus, a study in which 40 subjects has been designed. Twenty subjects were affected by bilateral wisdom tooth pathology necessitating for extraction of both teeth. Control group comprised 20 subjects with absence of wisdom teeth or completely erupted wisdom teeth without pathology associated to or history of previous extraction of both wisdom teeth.
In both groups a medical and dental examination will be performed at the baseline and 3 months after baseline for the control group or after the second third molar extraction in the control group. Blood will be also withdrawn to assess systemic inflammation and other systemic parameters.
Parameter were evaluated via high sensitive c reactive protein (CRP), lipids, fibrinogen, oxidative stress and endothelial function analysis.
- Detailed Description
Third molar extraction is one of the most frequent intervention in dentistry. Nevertheless, little is known about the systemic aspect of subjects with impacted or semi-impacted third molars and the possible effects of surgical removal on their systemic parameters. A case-control study of 40 subjects has been designed to evaluate i) the overall systemic inflammation and metabolism of subjects with bilateral third molars compared to subjects with no third molars and ii) the effect of bilateral removal in the immediate and medium postsurgical period. Systemic parameters are evaluated via high sensitive c reactive protein (CRP), lipids, fibrinogen, oxidative stress and endothelial function analysis.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 40
- cases: bilateral wisdom tooth pathology.
- control: agenesia/previous extraction/no symptoms of the lower third molars.
- younger than 18 years and older than 65 years;
- pregnant or lactating females;
- females using contraceptive methods;
- suffering from any systemic illness;
- undergoing any pharmacological treatment within 30 days prior to the inclusion
- patients affected by periodontal disease (radiographic diagnosis of vertical bone defects or bone resorption equal to 20% of the root length);
- patients with periapical and periradicular radiolucent areas X-ray detectable;
- patients unable to participate to study.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Cases: wisdom tooth pathology Wisdom tooth removal Subjects affected by bilateral wisdom tooth pathology, undergoing surgical removal
- Primary Outcome Measures
Name Time Method Changes in C-reactive protein (CRP) baseline, 24 and three months after the second extraction High-Sensitive plasmatic C-reactive protein
- Secondary Outcome Measures
Name Time Method Changes in plasma malondialdehyde (MDA) baseline, 24 and three months after the second extraction plasma malondialdehyde
Changes in lipoperoxides (LOOH) baseline, 24 and three months after the second extraction lipoperoxides levels in plasma
Changes in ferric-reducing antioxidant power (FRAP) baseline, 24 and three months after the second extraction FRAP levels in plasma
Changes in endothelial flow-mediated dilation (FMD) calculated as maximal percentual increase in diameter of the blood vessel above baseline baseline, 24 and three months after the second extraction Endothelium-dependent response of the brachial artery in response to increased blood flow by high resolution ultrasound with a 7.5 MHz linear array transducer