Collection and Analysis of the Clinical and Biological Characteristics of Patients Treated at Nîmes Carémeau University Hospital, for Giant Cells ARTEitis (Horton's Disease), for Diagnosis and During Long-term Follow-up
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 83
- 试验地点
- 1
- 主要终点
- Clinical and paraclinical characteristics of patients diagnosed with ACG
研究概览
简要总结
Giant cell arteritis (GCA) or Horton's disease: frequent large vessel vasculitis (cephalic) (incidence estimated at 9 per 100,000 in France), potentially responsible for blindness.
Treatment: corticosteroid therapy, which is effective in the vast majority of cases.
Clinical problem: relapse; 36% to 44% of patients have a relapse that occurs in the first year for many patients, requiring a re-escalation of corticosteroid therapy, with its consequences:
- Cumulative dose of corticosteroid therapy that causes cardiovascular and infectious morbidity.
- Requires additional immunosuppressive treatment.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 45 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients aged 45 years or older
- •Patients with giant cell arteritis according to ACR criteria or revised criteria incorporating imaging parameters,
- •Patients managed at the University Hospital of Carémeau in Internal Medicine from 01/01/2011 to 01/01/2020.
排除标准
- 未提供
结局指标
主要结局
Clinical and paraclinical characteristics of patients diagnosed with ACG
时间窗: day 1
Describe the clinical and paraclinical characteristics of patients diagnosed with ACG to determine whether certain characteristics are significantly associated with a higher risk of developing corticosteroid dependence
次要结局
未报告次要终点