How do hormones affect reproduction and metabolism in people with type 2 diabetes and people who do not have type 2 diabetes?

Not Applicable

Completed

• Conditions: Reproductive hormone effects; Nutritional, Metabolic, Endocrine

• Registration Number: ISRCTN10114288
• Lead Sponsor: Imperial College London

Brief Summary

2020 Results article in https://www.ncbi.nlm.nih.gov/pubmed/31628465 Effects of Peptide YY on the reproductive axis in healthy young men (added 03/12/2019) 2018 Results article in https://www.ncbi.nlm.nih.gov/pubmed/29974637 Effects of kisspeptin on glucose-stimulated insulin secretion, metabolites, gut hormones, appetite and food intake in healthy men (added 03/12/2019) 2023 Results article in https://pubmed.ncbi.nlm.nih.gov/37039248/ Effects of kisspeptin on food intake in women with overweight or obesity (added 17/04/2023) 2020 Results article in https://pubmed.ncbi.nlm.nih.gov/32232363/ Acute effects of glucagon on reproductive hormone secretion in healthy men (added 26/02/2024) 2020 Results article in https://pubmed.ncbi.nlm.nih.gov/32052032/ Effects of glucagon-like peptide-1 on the reproductive axis in healthy men (added 26/02/2024)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-12-09
• Study Completion: 2023-02-01
• Last Update Posted: 11 March 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 78

Inclusion Criteria

1. Aged 18 – 60 years
2. Male or female
3. Stable body weight for the preceding 3 months
4. 12-lead ECG with no clinically significant abnormalities as judged by the investigators
5. Full blood count, urea and electrolytes, thyroid function tests, liver function tests and glucose within 2 x the upper limit of normal
6. Conditions that predispose subfertility: BMI >25, Pre-diabetes, Type 2 diabetes

Exclusion Criteria

1. History of any medical, psychological or other condition, or use of any medications, including over-the-counter products, which, in the opinion of the investigators, would either interfere with the study or potentially cause harm to the volunteer
2. Pregnancy or breastfeeding
3. History of hypersensitivity to any of the components of the infusions
4. Treatment with an investigational drug within the preceding 2 months
5. Volunteers who have or intend to donate blood or blood products within three months before or following study completion
6. A history of alcoholism or substance abuse within the preceding 5 years
7. A history of major haematological, renal, thyroid or hepatic abnormalities or significant cardiovascular disease
8. A history of cancer
9. Volunteers with a medical or psychological condition that would impair their ability to participate reliably in the study or give informed consent
10. Smoker

Study & Design

• Study Type: Interventional
• Study Design: Not specified