Prospective study to evaluate trained immunity in kidney transplantatio
Recruiting
- Conditions
- niertransplantatiegraft survivalkidney transplantation
- Registration Number
- NL-OMON53183
- Lead Sponsor
- Radboud Universitair Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 100
Inclusion Criteria
Kidney transplant recipient
Age 18 - 80 years
Exclusion Criteria
No informed consent
Infection in the past four weeks
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>1. The trained immunity profile of monocytes from renal transplant patients.<br /><br>Before, one week after, and three months after renal transplantation, blood is<br /><br>drawn from patients and circulating monocytes are isolated to examine the<br /><br>activity, transcriptome, and epigenome of these monocytes.<br /><br><br /><br>2. The association between trained immunity and renal transplant survival.<br /><br>The association between the trained immunity profile as measured in (1) and<br /><br>graft survival in the first two years after transplantation is investigated.</p><br>
- Secondary Outcome Measures
Name Time Method <p>1. The association between trained immunity and inflammation and tissue damage.<br /><br>The association between the trained immunity profile as measured in (1) and<br /><br>markers for tissue damage and systemic inflammation is investigated.<br /><br><br /><br>2. The association between trained immunity and the concentration of<br /><br>immunosuppressive drugs in the blood of patients.<br /><br><br /><br>3. The association between trained immunity and the amount of white blood cells<br /><br>and subsets of white blood cells.</p><br>