Surgery-Oriented Classification and Treatment Strategy for Adult Congenital Biliary Dilation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 234
- 试验地点
- 1
- 主要终点
- The modified Mayo Clinic score for CBD
研究概览
简要总结
The management of congenital biliary dilations (CBDs), including choledochal cysts, represents one of the most challenging areas in hepatobiliary surgery due to their potential implications for long-term morbidity and malignant transformation. While CBDs have a relatively low incidence in Western populations (1/150,000-1/100,000), the prevalence is notably higher in Asian countries (1/1,000), making it a significant global health concern. Although complete surgical resection remains the standard of care, the optimal extent of resection and reconstruction strategy, particularly for complex disease patterns, continues to be debated. To address these challenges, the current study proposes a novel surgery-oriented classification system for adult CBD based on the analysis of 234 consecutive cases.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age: Adults (≥18 years).
- •Study population: Consecutive patients treated at Beijing Tsinghua Changgung Hospital.
- •Time frame: Underwent surgical treatment between November 2014 and October
- •Condition/Procedure: Underwent surgical treatment for common bile duct (CBD) diseases.
- •Diagnostic confirmation: Presence, location, and extent of CBD dilatation were diagnosed by preoperative imaging/radiology, and confirmed intraoperatively.
排除标准
- •1.Secondary biliary dilatation due to proximal obstruction, including intrahepatic and/or extrahepatic bile duct dilatation caused by proximal biliary obstruction, such as:
- •benign stricture,
- •malignant stricture,
- •obstructive stones.
研究组 & 干预措施
underwent surgical treatment for CBD between November 2014 and October 2024
干预措施: hepatectomy、liver transplantation、hepaticojejunostomy (Procedure)
结局指标
主要结局
The modified Mayo Clinic score for CBD
时间窗: Last follow-up time (assessed up to 10 year)
Patients were stratified into excellent, good, fair, and poor categories based on established criteria
次要结局
- perioperative complications(Perioperative period（Within 3 months after surgery）)
- long-term disease-free survival(Last follow-up time (assessed up to 10 year))
研究者
Shuo Jin
Associate Chief Physician
Beijing Tsinghua Chang Gung Hospital