The Effects of a Combined Exercise Training Program on Vascular Health and Metabolic Profile in Obese Adolescent Girls.
- Conditions
- Obesity, Adolescent
- Interventions
- Behavioral: Combined Exercise Training
- Registration Number
- NCT03146026
- Lead Sponsor
- Pusan National University
- Brief Summary
The purpose of this study was to examine the impact of 12 weeks of combined exercise training (CET) on arterial stiffness, endothelial function, inflammatory markers, insulin resistance, and body composition in obese adolescent girls. Thirty obese adolescent girls participated in this study. The girls were randomly divided into CET group (n=15) and control group (n=15). The CET group performed concurrent resistance training followed by aerobic training at 40-70% of the heart rate reserves (HRR) 3 days/week for 12 weeks. Plasma nitric oxide, endothelin-1, C-reactive protein, arterial stiffness, homeostasis model assessment of insulin resistance (HOMA-IR), glucose, insulin, and the adiponectin/leptin ratio were measured before and after the 12-weeks study.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 30
- Obese with hyperinsulinemia
- Abdominal obesity
- Sedentary (no regular exercise training or physical activity)
- No weight loss diet during last 6 months.
- Hypertension
- Pregnancy
- Chronic disease
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Combined Exercise Training (CET) Combined Exercise Training Fifteen obese adolescent girls. This arm performed combined exercise training 3 times per a week for 12 weeks. Caloric intake was 1921.7 kcal/day.
- Primary Outcome Measures
Name Time Method Body fat 12 weeks Percent body fat (%) was determined using a bioelectrical impedance-meter.
Plasma adiponectin 12 weeks Plasma adiponectin was measured using ELISA kit
Insulin resistance 12 weeks Insulin resistance was estimated using the homeostasis model assessment of insulin resistance (HOMA-IR).
Waist circumference 12 weeks Waist circumference was measured at midpoint between the lower rib and the iliac crest at the end of a normal expiration using a tape measure
Maximal heart rate 12 weeks Maximal heart rate was obtained at the end of a graded treadmill exercise test performed until volitional exhaustion.
Nitric oxide 12 weeks Nitric oxide generation was measured by Griess assay kit.
Endothelin-1 12 weeks Levels of Endothelin-1 in blood were measured by Endothelin-1 enzyme immunoassay kit.
Body weight 12 weeks Body weight was measured to nearest 0.1 kg.
Height 12 weeks Height was measured to nearest 1 cm.
Arterial stiffness 12 weeks Arterial stiffness was measured as measurement of baPWV (m/s).
Plasma leptin 12 weeks Plasma leptin was determined by ELISA kit
- Secondary Outcome Measures
Name Time Method