Mapping the Health Status of the Population of French Polynesia: the MATAEA Project
- Conditions
- MicrobiomeNon Communicable DiseasesCommunicable DiseasesPesticide ExposureMetal PoisonGenetics PopulationCiguatera
- Interventions
- Other: QuestionnaireOther: Physical measurementsOther: Biological samples
- Registration Number
- NCT06133400
- Lead Sponsor
- Institut Louis Malardé
- Brief Summary
This is a cross-sectional study carried out on a sample of the adult population aged 18 to 69, distributed over the five archipelagos of French Polynesia.
Participation in the study involves: agreement to answer a questionnaire to collect information on socio-demographic characteristics, lifestyle habits and medical history; physical measurements (height, weight, waist circumference, blood pressure and skin pigmentation); and agreement to take biological samples (blood, saliva and stool) for biological, genetic and microbiological analyses.
The aim of the study is to assess the current health status of the population of French Polynesia and to evaluate the influence of contextual risk factors (lifestyle, place of residence, history of infection) and intrinsic susceptibility factors (genetics, age, gender, microbiota) in relation to non-communicable and infectious diseases.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 1942
- be aged 18 or over and under 70 on the date of recruitment
- having signed the consent form
- Minors
- Pregnant or parturient women, and nursing mothers
- Persons deprived of their liberty by a judicial or administrative decision
- Adults who are the subject of a legal protection measure or who are unable to express their consent
- People undergoing psychiatric care
- Individuals who are not affiliated to a social security scheme or beneficiaries of such a scheme
- Homeless people
- Disabled people (unable to move)
- People unable to answer the questionnaire
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Subjects representative of the adult population (18-69 y) of French Polynesia Questionnaire Population sample composed of people aged 18 to 69. These people must have been living in French Polynesia for more than two years at the time of the 2017 census Subjects representative of the adult population (18-69 y) of French Polynesia Physical measurements Population sample composed of people aged 18 to 69. These people must have been living in French Polynesia for more than two years at the time of the 2017 census Subjects representative of the adult population (18-69 y) of French Polynesia Biological samples Population sample composed of people aged 18 to 69. These people must have been living in French Polynesia for more than two years at the time of the 2017 census
- Primary Outcome Measures
Name Time Method Prevalence of cardiovascular diseases 2 years Proportion of participants with indicators of cardiovascular diseases based on self-reported data on history of hypertension (previous diagnosis, treatment for hypertension), blood pressure measurement, and quantification of lipid levels from blood samples.
Association between non-communicable diseases and behavioral factors 2 years Calculation of odd ratios to investigate association between non-communicable diseases (obesity, diabetes, cardiovascular diseases) and behavioral factors such as tobacco smoking, alcohol consumption, diet or physical activity data self-reported by the participants in the questionnaire.
Association between non-communicable diseases and blood analyses 2 years Calculation of odd ratios to investigate association between non-communicable diseases (obesity, diabetes, cardiovascular diseases) and blood analyses (such as glycated haemoglobin and lipid levels).
Composition of microbiome 2 years Bacterial DNA sequencing from stool and saliva samples to assess the gut and oral microbiota profiles and association with lifestyle behavior, diet and susceptibility to communicable and non-communicable diseases.
Prevalence of diabetes 2 years Proportion of participants with indicators of diabetes based on self-reported data on diabetes history (previous diagnosis, antidiabetic treatment) and quantification of glycated haemoglobin from blood samples.
Association between non-communicable diseases and physical measurements 2 years Calculation of odd ratios to investigate association between non-communicable diseases (obesity, diabetes, cardiovascular diseases) and physical measurements such as BMI (based on the BMI formula i.e., weight in kilograms divided by height in meters squared).
Level of exposure to heavy metals 2 years Quantification of levels of heavy metals (including mercury and lead) from blood samples and association with lifestyle behavior and diet.
Level of exposure to mosquito bites 2 years Proportion of participants with IgG antibodies targeting mosquito salivary proteins in blood samples to assess the risk of infection by mosquito-borne viruses
Genetic susceptibility to communicable diseases 2 years Genome-wide association studies to identify human genetic factors that are associated with the detection of IgG antibodies specific for different pathogens: arboviruses, hepatitis B and C viruses, hantaviruses, SARS-CoV-2 and other pathogens known to regularly cause infections in French Polynesia (including influenza viruses, human immunodeficiency virus...).
Prevalence of obesity 2 years Proportion of participants with indicators of obesity based on physical measurements (BMI, waist circumference) and quantification of lipid levels from blood samples.
Seroprevalence of communicable diseases 2 years Proportion of participants with IgG antibodies, detected in blood samples, specific for different pathogens : arboviruses (four dengue serotypes, Zika, chikungunya), hepatitis B and C viruses, hantaviruses, SARS-CoV-2 and other pathogens known to regularly cause infections in French Polynesia (including influenza viruses, human immunodeficiency virus...). Proportion of participants with positive filarial antigenemia to assess the prevalence of Bancroftian lymphatic filariasis.
Level of exposure to pesticides 2 years Quantification of levels of pesticides (including chlordane and toxaphene) from blood samples and association with lifestyle behavior and diet.
Prevalence of ciguatera poisoning 2 years Estimation of the rate of ciguatera poisoning in the population based on data self-reported by the participants in the questionnaire e.g. the occurrence of symptoms suggestive for ciguatera poisoning at least once in their lifetime
Demographic and adaptive history of French Polynesians using genomics 2 years Human Whole Genome Sequencing from saliva samples to reconstruct the genetic history of the population of French Polynesia, in terms of both demographic and adaptive history.
Genetic susceptibility to obesity 2 years Genome-wide association studies to identify human genetic factors that are associated with BMI or lipids levels.
Genetic susceptibility to diabetes 2 years Genome-wide association studies to identify human genetic factors that are associated with HbA1c.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Institut Louis Malardé
🇵🇫Papeete, Tahiti, French Polynesia