Proprioception and Sensorimotor Control in Hereditary Sensory and Autonomic Neuropathy

Not Applicable

Completed

• Conditions: Atunomic Neuropathy
• Interventions: Other: kinesiology tape around the hip, knee and ankle joints; Other: No kinesiology tape around the hip, knee and ankle joints

• Registration Number: NCT02876939
• Lead Sponsor: NYU Langone Health

Brief Summary

This project comprises three sets of physiological studies - testing eight specific hypotheses - that will contribute new knowledge on proprioception and motor control in a genetic disorder that affects specific components of the sensory nervous system.

I: To investigate the neurophysiological basis for disturbed motor control in Hereditary sensory and autonomic neuropathy (HSAN) III II: To investigate the effects of enhancing cutaneous feedback on motor control in HSAN III III: To investigate the cortical representation of proprioceptive inputs in HSAN III

Detailed Description

HSAN III patients (n=15) and healthy control subjects (n=15) will lay supine on an MRI bed and a tungsten microelectrode inserted percutaneously into a muscle or cutaneous fascicle of the right common peroneal nerve at the fibular head, according to standard techniques employed by Prof Macefield. Neural activity will be acquired, RMS-processed (200 ms) and analysed on computer. The subject's head will be tightly enclosed in a standard clinical 32-channel SENSE head coil and headphones will be provided to minimize noise and to allow communication with the subject. The subject will be placed in the bore of a 3T whole-body scanner for 60-90 minutes.

Study Timeline

• Study First Submitted: 2016-08-05
• Study First Submitted QC: 2016-08-18
• Study First Posted: 2016-08-24
• Study Start: 2016-11
• Primary Completion: 2019-07-25
• Study Completion: 2019-07-25
• Status Verified: 2020-09
• Last Update Submitted: 2020-09-18
• Last Update Posted: 2020-09-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 16

Inclusion Criteria

• Confirmed genetic diagnosis of HSAN III will be recruited from the Dysautonomia Center at NYU

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Exclusion Criteria

• homeless
• active drug or alcohol dependence
• evidence of neurological disorder or diabetes
• exposure to neurotoxic drugs that in the investigator's opinion may compromise results
• Pregnant women

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
HSAN III	No kinesiology tape around the hip, knee and ankle joints	-
Control Subjects	No kinesiology tape around the hip, knee and ankle joints	-
HSAN III	kinesiology tape around the hip, knee and ankle joints	-
Control Subjects	kinesiology tape around the hip, knee and ankle joints	-

Primary Outcome Measures

Name	Time	Method
Measurement of gait in HSAN III	120 Minutes

Trial Locations

Locations (1)

New York University School of Medicine; 🇺🇸 New York, New York, United States