Research on Determining Normal Binding Extent of Dopamine Transporter Binding Ratio using 123I-FP-CIT SPECT

Not Applicable

• Conditions: ormal healthy control

• Registration Number: JPRN-UMIN000018045
• Lead Sponsor: Department of Neurology,Juntendo University

Brief Summary

A strong correlation between the SBR and age was observed. The correlation coefficient in males and females were -0.566 and -0.502, respectively. The analysis of variance revealed that aging led to a decline of the SBR, and a significant difference (p=0.005) was observed among generations. Gender also affected the SBR, and there was a significant difference between males and females (p=0.036). The SBR in females was higher than in males. Consequently, the multiple comparison revealed a significant difference between 50s and 70s (p=0.015) and 50s and 80s (p=0.006).

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-06-30
• Study Completion: 2016-06-30
• Last Update Posted: 20 November 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Not provided

Exclusion Criteria

1) Individuals who are pregnant, possibly pregnant, or lactating 2) Individuals with past history of alcoholism, or alcoholics currently under treatment 3) Individuals with past history of epilepsy, or epileptics currently under treatment 4) Individuals with less than 6-year education 5) Individuals who are prescribed with antidepressant or psychotropics, or sedatives including anti-anxiety agents for a long time 6) Individuals with past history of mental or neurological illnesses which affect cognitive functions 7) Individuals with serious complications such as hepatopathy, nephropathy, or endocrinopathy 8) Individuals taking the below mentioned drugs that are considered to affect on accumulation of 123I FP-CIT in the brain within a month after administering the same: cocaine hydrochloride, mazindol, methylphenidate hydrochloride, sertraline hydrochloride, and selective serotonin reuptake inhibitor 9) Individuals judged inappropriate for accomplishing our objective by the principal investigator, researchers in charge, or cooperative researchers

Study & Design

• Study Type: Interventional
• Study Design: Not specified