Visual Function Changes After Intraocular Pressure Reduction
- Conditions
- Glaucoma
- Registration Number
- NCT00435058
- Lead Sponsor
- University of Sao Paulo
- Brief Summary
During the glaucomatous disease process, subpopulations of cells may be dead, damaged or healthy. Visual function changes could be observed due to a recovering of the suffering ganglion cells after the intraocular pressure reduction. This study aims at evaluating the correlation between intraocular pressure reduction and visual function changes in glaucoma patients after using antiglaucoma medications.
- Detailed Description
Primary open angle glaucoma patients without use of antiglaucoma medications will be enrolled in this study. After inclusion, the patients will randomly receive one of three antiglaucoma medications (timolol maleate 0,5%, brimonidine tartrate 0,2% or travoprost 0,004%) in one randomly selected eye.
The patients will be evaluated with Goldmann applanation tonometry, visual acuity test, contrast sensitivity test, visual quality perception test (visual analogue scale) and standard automated perimetry before and after 4 weeks of glaucoma treatment onset.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 54
- Primary open angle glaucoma
- Intraocular pressure greater than 21 mmHg
- Best corrected visual acuity (BCVA) worse than 20/80
- Significant media opacity
- History of steroid use
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method intraocular pressure contrast sensitivity visual quality perception
- Secondary Outcome Measures
Name Time Method Mean deviation of the visual field (MD) Pattern Standard Deviation of the visual field (PSD) visual acuity