NCT01929239暂停1 期
Phase Ia/Ib Trial of Anti-PSMA Designer T Cells in Prostate Cancer After Non-Myeloablative Conditioning
适应症
干预措施
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 暂停
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- Number of participants with adverse events
研究概览
简要总结
This is a Phase Ib Pilot study of anti-PSMA designer T cells in metastatic prostate cancer. Subjects will receive escalating doses of T cells, with either low or moderate dose Interleukin 2. The T cells are collected by pheresis and then genetically modified, and given in a one time infusion.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •5.2.1 Patient with histologically confirmed diagnosis of prostate cancer.
- •5.2.2 Patient with rising serum PSA,(prostate specific antigen).
- •5.2.3 Tumor is hormone refractory, as documented by rising PSA with two values separated in time. Patients may enroll if they have a rising PSA after withdrawal of androgen therapy but if enrolled onto this protocol on androgen ablation therapy, they must remain on the androgen therapy for the duration of this protocol. Patients may enroll if tumor is not hormone refractory only if they refuse hormone therapy at this time, and that they understand that hormone therapy is standard treatment for their disease at this stage.
- •5.2.4 Patient must be at least 18 years of age.
- •5.2.5 Patient able to understand and sign informed consent.
- •5.2.6 Patient with a life expectancy of greater than four months.
- •5.2.7 Patient with performance status of 0 to
- •(http://www.ecog.org/general/perf_stat.html).
- •5.2.8 Patient with adequate organ function as defined by:
- •5.2.8.1 ANC 1.0, platelets 50,000, Hgb 8.0; patient may be transfused to achieve Hgb 8.0 to satisfy enrollment criteria, or as otherwise indicated by symptoms for Hgb >8.
- •5.2.8.2 Creatinine 1.5mg/dl or creatinine clearance 60cc/min.
- •5.2.8.3 Direct bilirubin 1.5 mg/dl.
- •5.2.8.4 No evidence of congestive heart failure, symptoms of coronary artery disease, serious cardiac arrhythmias, including atrial fibrillation/atrial flutter, evidence of prior myocardial infarction by history or EKG. A normal cardiac stress test for inducible ischemia or arrhythmia within 12 weeks prior to enrollment for all patients over 50 years old or those with abnormal EKG or any history or symptoms suggestive of cardiac disease.
- •5.2.8.5 No serious, symptomatic obstructive or emphysema¬tous lung disease, or asthma requiring intravenous medications within the past 12 months; no serious lung disease associated with dyspnea at normal activity levels (grade III) or at rest (grade IV), due to any cause (including cancer metastases and pleural effusions). The patient will be ineligible if PFTs show an FEV1 <1.3 liters or a DLCO <50% within 12 weeks of study entry.
- •For patients enrolling in cohorts IIA, IIB, and III:
- •5.2.9 Patients with disease in the bone or other site(s) have biopsy-able tumor (at radiologically- or externally-accessible site), and willing to undergo biopsy as specified in 6.3.
- •For these groups, patients with >5 lesions bone scan positive lesions will be preferred to increase the yield of blind bone marrow biopsies.
- •Alternatively, patients with bone or extra-skeletal lesions may be biopsied by CT guided or open procedure.
排除标准
- •5.3.1 Patients with serious or unstable renal, hepatic, pulmonary, cardiovascular, endocrine, rheumatologic, or allergic disease based on history, physical exam and laboratory tests will be excluded, as outlined in section 5.2.
- •5.3.2 Patients with active clinical disease caused by CMV, hepatitis B or C, HIV or tuberculosis will be excluded from the study.
- •5.3.3 Patients who have had cytotoxic and/or radiation therapy in the four weeks prior to entry or who have initiated anti-androgen therapy less than six weeks prior to entry will be excluded.
- •5.3.4 Patients with other concurrent malignancies will be excluded.
- •5.3.5 Patients requiring systemic steroids will be excluded.
- •5.3.6 Patients with prior investigational therapies within the 4 weeks prior to entry will be excluded.
- •5.3.7 Patients previously exposed to mouse antibody will be excluded, unless proven by ELISA to have a negative baseline human anti-mouse antibody (HAMA) titer.
- •5.3.8 Patients who have had irradiation to whole pelvis or to more than 25% of total marrow will be excluded.
研究组 & 干预措施
Anti PSMA Designer T Cells
Experimental
Open Label, subjects receive anti PSMA designer T cells, plus IL2, low or moderate dose.
干预措施: Anti-PSMA Designer T Cells (Drug)
结局指标
主要结局
Number of participants with adverse events
时间窗: 30 days
次要结局
未报告次要终点
研究者
研究点 (1)
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