HNC: Human Neural Circuits Electrophysiology During Cognition
试验速览
- 阶段
- 1 期
- 状态
- 招募中
- 入组人数
- 120
- 试验地点
- 2
- 主要终点
- Number of participants with dissociative events during ketamine infusion as assessed by CADSS (Clinician-Administered Dissociative State Scale)
研究概览
简要总结
The purpose of this study is to understand how ketamine brings about dissociative symptoms.
详细描述
The goal of this proposed research is to record the effects of ketamine on brain activity to understand the changes that occur during antidepressant therapy and the side effect of dissociation. This research is designed to probe altered cognitive states associated with dissociation, depression, and other neuropsychiatric conditions.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient in clinical neuro inpatient units at Stanford Medical Center
- •Age >18 years old
- •Female participants are expected to use an effective method of birth control throughout the study which includes: hormonal methods (birth control pills, patches, injections, vaginal ring or implants), barrier methods (condom or diaphragm) used with spermicide, intrauterine device (IUD), or abstinence (no sex)
排除标准
- •Lifetime psychotic disorder
- •Pregnant or nursing females
- •Prior adverse ketamine response
- •Use of ketamine in past 7 days
研究组 & 干预措施
Ketamine
Study participants will receive 0.5mg/kg of ketamine - one single infusion
干预措施: Ketamine Hydrochloride (Drug)
结局指标
主要结局
Number of participants with dissociative events during ketamine infusion as assessed by CADSS (Clinician-Administered Dissociative State Scale)
时间窗: up to 1 week
The CADSS is an instrument for the measurement of dissociative symptoms. The CADSS comprises 23 subjective items and participant's responses are coded on a 5-point scale (0 = Not at all; 4 = Extreme). The higher the number on the CADSS, the more severe the symptoms.
次要结局
未报告次要终点
研究者
Karl Deisseroth
Professor
Stanford University