Individualized Open Lung PEEP in Thoracic Surgery: A Prospective Multicenter Observational Study in 17 Spanish Hospitals
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Thoracic Surgery
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
- Enrollment
- 690
- Primary Endpoint
- Postoperative pulmonary complications
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
During thoracic surgical procedures, while ventilating with a protective tidal volume, an open lung approach consisting of a recruitment maneuver followed by an individualized positive end-expiratory pressure (PEEP) titrated to best respiratory system compliance (Open-lung PEEP, OL-PEEP) would decrease driving pressure. To test this hypothesis, we performed a multicenter observational study in 17 Spanish teaching hospitals of patients undergoing one lung ventilation (OLV). In addition, we analyzed the association between the driving pressure and the prevalence of postoperative pulmonary complications (PPCs), and finally the association between the individualized PEEP and relevant patient preoperative or intraoperative variables.
Investigators
Carlos Ferrando
Principal investigador
Fundación para la Investigación del Hospital Clínico de Valencia
Eligibility Criteria
Inclusion Criteria
- •Patients undergoing one lung ventilation
Exclusion Criteria
- •No exclusion criteria
Outcomes
Primary Outcomes
Postoperative pulmonary complications
Time Frame: Postoperative. One week
Atelectasis, acute respiratory failure, ARDS, pneumonia, reintubation, empyema, bronchospasm, pneumothorax, pneumonitis, bronchopleural fistula
Secondary Outcomes
- Descriptive analysis of the open lung PEEP(intraoperative)