Automated Breast Radiation Therapy Using an MR-Guided Process

Not Applicable

Active, not recruiting

• Conditions: Breast Cancer
• Interventions: Other: IMRT + CT + MR scan

• Registration Number: NCT01999062
• Lead Sponsor: University Health Network, Toronto

Brief Summary

In the proposed research study, we are investigating the feasibility of integrating automated planning tools to MR images acquired using a novel MR-guided linac, for on-line adaptive radiation treatment. However, these on-line automation tools require further technical refinement and clinical validation. The goal of this research proposal is to develop an on-line MR-guided radiation therapy process for adapting breast IMRT treatment. Such an approach will provide early stage breast cancer patients timely access to high-quality adaptive treatments without exposure to additional ionizing radiation.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-03
• Study First Submitted: 2013-06-11
• Study First Submitted QC: 2013-11-25
• Study First Posted: 2013-12-03
• Status Verified: 2025-03
• Last Update Submitted: 2025-03-03
• Last Update Posted: 2025-03-06
• Primary Completion: 2027-09
• Study Completion: 2027-09

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: Female
• Target Recruitment: 160

Inclusion Criteria

• Patients who will receive standard two-field tangential whole breast radiation therapy with dose prescription of 4240 cGy in 16 fractions, 5000 cGy in 25 fractions or 4000 cGy in 16 fractions.
• Female patients with any stage of breast cancer.
• Patients with prior treatment such as surgery or chemotherapy for any type of cancer.
• Able to provide a written informed consent.
• ≥ 18 years of age.

Exclusion Criteria

• Patients who will not receive 4240 cGy in 16 fractions, 5000 cGy in 25 fractions, or 4000 cGy in 16 fractions
• Males.
• Patients who received partial breast radiation and not the standard dose.
• Patients who are unable to provide informed consent.
• < 18 years of age.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
IMRT + CT + MR scan	IMRT + CT + MR scan	-

Primary Outcome Measures

Name	Time	Method
The effect of breathing on the position of the heart and lung in treatment plans	3 years
Time between planning of Radiation treatment and the start of radiotherapy	3 years

Trial Locations

Locations (1)

Princess Margaret Cancer Centre; 🇨🇦 Toronto, Ontario, Canada