Comparative evaluation of the efficacy of locally delivered hyaluronic acid with tetracycline fiber as an adjunct to scaling and root planing for the treatment of periodontitis Stage II/III in smokers- A randomized controlled trial.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 128
- 试验地点
- 1
- 主要终点
- Probing depth
研究概览
简要总结
The prevalence, extent and severity of periodontitis is more in smokers. After surgical therapy there is less probing depth reduction, less gain in clinical attachment level, less bone fill and increased recession and deterioration of furcation. Hyaluronic acid has anti-inflammatory properties and is known to facilitate healing by inhibiting tissue destruction. Tetracycline fiber are known to exert an anticollagenase effect that can inhibit tissue destruction and may help with bone regeneration. Since, surgical therapy in smokers is less predictable, use of Hyaluronic acid and tetracycline fiber as an LDD can serve as an alternate treatment modality in such population.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant and Outcome Assessor Blinded
入排标准
- 年龄范围
- 30.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Participants diagnosed with periodontitis Stage II/III.
- •Participants who are current smokers, smoking ≥10 cigarettes/ bidis per day since at least 1 month.
- •Participants should not have received any periodontal therapy for past 6 months.
- •Participants who gave consent to participate in the study.
排除标准
- •Pregnant and lactating women.
- •Patients using anti-microbial mouthwash in the past 2 months.
- •Participants with allergy to hyaluronic acid.
- •Participants with systemic disease other than diabetes mellitus.
结局指标
主要结局
Probing depth
时间窗: 4 weeks | 12 weeks
Clinical attachment level
时间窗: 4 weeks | 12 weeks
Radiographic bone fill
时间窗: 4 weeks | 12 weeks
次要结局
- Plaque index(Sulcus bleeding index)
研究者
Aishwarya Pratihari
K M Shah Dental College and Hospital