Study of Valemetostat Tosylate Monotherapy in Subjects withRelapsed/Refractory Peripheral T-Cell Lymphoma

Recruitment & Eligibility

Status: ot Recruiting

Sex: All

Target Recruitment: 147

Inclusion Criteria

Written informed consent, Subjects =18 years of age or the minimum legal adult age (whichever is greater) at the time the ICF is signed., Eastern Cooperative Oncology Group (ECOG) performance status (PS) of 0, 1, or 2, Cohort 1 (R/R PTCL): Diagnosis should be confirmed by the local pathologist; local histological diagnosis will be used for eligibility determination. Subjects with the following subtypes of PTCL are eligible, according to 2016 World Health Organization classification prior to the initiation of study drug. Any T-cell lymphoid malignancies not listed below are excluded. Below is the complete list of eligible subtypes: - Enteropathy-associated T-cell lymphoma - Monomorphic epitheliotropic intestinal T-cell lymphoma - Hepatosplenic T-cell lymphoma - Primary cutaneous ?d T-cell lymphoma - Primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma - PTCL, not otherwise specified - Angioimmunoblastic T-cell lymphoma - Follicular T-cell lymphoma - Nodal PTCL with TFH phenotype - Anaplastic large cell lymphoma, ALK positive - Anaplastic large cell lymphoma, ALK negative, Cohort 2 (R/R ATL): Acute, lymphoma, or unfavorable chronic type. R/R ATL should be confirmed by the local pathologist; local diagnosis will be used for eligibility determination. The positivity of anti-HTLV-1 antibody will be locally determined for eligibility, Must have at least one of the following lesions which are measurable in 2 perpendicular dimensions on computed tomography (or magnetic resonance imaging) based on local radiological read, Documented refractory, relapsed, or progressive disease after at least 1 prior line of systemic therapy. Refractory is defined as - Failure to achieve CR (or uncertified CR [CRu] for ATL) after first-line therapy; or - Failure to reach at least PR or stable disease) after second-line therapy or beyond, Must have at least 1 prior line of systemic therapy for PTCL or ATL. - Subjects must also be considered as HCT ineligible during Screening due to disease status (active disease), comorbidities, or other factors; the reason for HCT ineligibility must be clearly documented - In Cohort 1, subjects with ALCL must have prior brentuximab vedotin treatment

Exclusion Criteria

Diagnosis of mycosis fungoides, Sézary syndrome, and primary cutaneous ALCL and systemic dissemination of primary cutaneous ALCL, History of treatment with other EZH inhibitors, Current use of moderate or strong cytochrome P450 (CYP)3A inducers (Table 10.4), Systemic treatment with corticosteroids (>10 mg daily prednisone equivalents). Note: Short-course systemic corticosteroids (eg, prevention/treatment for transfusion reaction) or use for a non-cancer indication (eg, adrenal replacement) is permissible, Known or suspected hypersensitivity to valemetostat tosylate or any of the excipients, Diagnosis of precursor T-cell lymphoblastic leukemia and lymphoma (T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma), T-cell prolymphocytic leukemia, or T-cell large granular lymphocytic leukemia, Prior malignancy active within the previous 2 years except for locally curable cancer that is currently considered as cured, such as cutaneous basal or squamous cell carcinoma, superficial bladder cancer, or cervical carcinoma in situ, or an incidental histological finding of prostate cancer, Presence of active central nervous system (CNS) involvement of lymphoma, History of autologous HCT within 60 days prior to first dose of study drug, History of allogeneic HCT within 90 days prior to the first dose of study drug, Clinically significant graft-versus-host disease (GVHD) or GVHD requiring systemic immunosuppressive prophylaxis or treatment, Inadequate washout period from prior lymphoma-directed therapy before enrollment, defined as follows: - Prior systemic therapy (eg, chemotherapy, immunomodulatory therapy, or monoclonal antibody therapy) within 3 weeks or 5 half-lives of the drug, whichever is longer, prior to the first dose of study drug - Had curative radiation therapy or major surgery within 4 weeks or palliative radiation therapy within 2 weeks prior to the first dose of study drug, Uncontrolled or significant cardiovascular disease, including: - Evidence of prolongation of QT/QTc interval (eg, repeated episodes of QT corrected for heart rate using Fridericia's method [QTcF] >450 ms) (average of triplicate determinations) - Diagnosed or suspected long QT syndrome, or known family history of long QT syndrome - History of clinically relevant ventricular arrhythmias, such as ventricular tachycardia, ventricular fibrillation, or Torsade de Pointes - Uncontrolled arrhythmia (subjects with asymptomatic, controllable atrial fibrillation may be enrolled), or asymptomatic persistent ventricular tachycardia - Subject has clinically relevant bradycardia of = 50 bpm unless the subject has a pacemaker - History of second- or third-degree heart block. Candidates with a history of heart block may be eligible if they currently have pacemakers, and have no history of fainting or clinically relevant arrhythmia with pacemakers, within 6 months prior to Screening - Myocardial infarction within 6 months prior to Screening - Angioplasty or stent graft implantation within 6 months prior to Screening - Uncontrolled angina pectoris within 6 months prior to Screening - New York Heart Association (NYHA) Class 3 or 4 congestive heart failure - Coronary/peripheral artery bypass graft within 6 months prior to Screening - Uncontrolled hypertension (resting systolic blood pressure >180 mmHg or diastolic blood pressure >110 mmHg) - Complete left bundle branch block

Study & Design

Study Type: Interventional clinical trial of medicinal product

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method

Secondary Outcome Measures

Name	Time	Method

Related Trials

Single-Arm, Phase 2 Study of Valemetostat Tosylate Monotherapy in Subjects with Relapsed/Refractory Peripheral T-Cell Lymphoma

CompletedPhase 2

Daiichi Sankyo Inc.

Updated 4/23/2024