Impact of a Family History of Hypertension and Physical Activity on Left Ventricular Mass

Completed

• Conditions: Genetic Predisposition; Genetic Hypertension
• Interventions: Other: Family history of hypertension

• Registration Number: NCT05334355
• Lead Sponsor: Montclair State University

Brief Summary

This is a retrospective analysis of data collected within two previous studies. The data has been combined and used to investigate the impact of having a family history of hypertension on left ventricular muscle mass with and without controlling for moderate and vigorous intensity physical activity frequency per week. The hypothesis was that in a sample of mostly active participants, no differences in left ventricular mass between family history of hypertension groups would be observed, but the positive family history of hypertension group would have elevated left ventricular mass compared to the negative family history of hypertension group following statistical control of activity frequency.

Detailed Description

A positive family history of hypertension (FHH) (+FHH) is associated with elevated left ventricular mass (LVM). Regular physical activity (PA) may eliminate differences in LVM between +FHH and negative family history of hypertension (-FHH) adults. PURPOSE: To determine if a +FHH is associated with a greater LVM compared to a -FHH group within a sample of young, mostly active healthy adults with and without statistically controlling for PA. METHODS: Healthy young (18-32yrs) participants self-reported FHH status and habitual moderate and vigorous PA frequency. Participants then underwent an echocardiogram.

Study Timeline

• Study Start: 2016-04-19
• Primary Completion: 2020-02-27
• Study Completion: 2020-02-27
• Study First Submitted: 2022-04-01
• Study First Submitted QC: 2022-04-12
• Study First Posted: 2022-04-19
• Results First Submitted: 2023-03-14
• Status Verified: 2025-02
• Results First Submitted QC: 2025-02-20
• Last Update Submitted: 2025-02-20
• Results First Posted: 2025-02-24
• Last Update Posted: 2025-02-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 74

Inclusion Criteria

• Generally healthy

Exclusion Criteria

• Known hypertension, cardiovascular disease, current pregnancy, current infectious disease, diabetes mellitus, kidney disease, a history of cancer, pulmonary disease, history of a stroke, obesity (for most people this means a body mass index greater than 30), or any life threatening chronic conditions

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Positive Family History of Hypertension	Family history of hypertension	Young normotensive generally healthy adult with one or more biological parents with diagnosed hypertension.

Primary Outcome Measures

Name	Time	Method
Left Ventricular Mass	Day 2	Muscle mass in grams of the left ventricle of the heart as estimated by ultrasound.