Prospective randomized controlled study for the therapeutic effect of removing uremic toxins on endothelial function in undialyzed patients with chronic renal failure
Not Applicable
- Conditions
- ndialyzed patients with chronic renal failure
- Registration Number
- JPRN-UMIN000001379
- Lead Sponsor
- Division of Nephrology, Department of Internal Medicine, Kawasaki Medical School
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
Not provided
Exclusion Criteria
(1) Patients with obstructive or stenotic diseases of digestive organs. (2) Patients with the nephrotic syndrome. (3) Patients with acute renal failure, rapid elevation of serum creatinine or active nephropahty in the last 6 months. (4) Patients with inflammatory or consumptive diseases (e.g. infection, malignancy). (5) Patients with severe cardiovascular diseases (e.g. heart failure, coronary disease, cerebrovascular disease, peripheral vascular disease). (6) Dialyzed patients. (7) Patients treated by AST-120. (8) Patients treated by steroids or immunosuppressive agents. (9) Females in pregnancy. (10) Patients judged as unsuitable for participating in this study by the attending physician.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Flow-mediated vasodilation of branchial artery
- Secondary Outcome Measures
Name Time Method Changes of the below parameters: (1) Systolic and diastolic blood pressure (2) Creatinine clearance (Ccr) (3) Urinary protein excretion (UPE) (4) Mediators associated with endothelial function