Clinical, Electrophysiological and Biological Diagnostic Criteria of Sensory Neuronopathies
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Neuronopathy
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
- Enrollment
- 80
- Locations
- 12
- Primary Endpoint
- Likelihood ratio diagnostic criteria established on the study population
- Status
- Terminated
- Last Updated
- 9 years ago
Overview
Brief Summary
The diagnosis of sensory neuronopathy is difficult to establish because the only certainty criterion is based on the detection of specific lesions in the posterior spinal ganglion which is usually not possible. There is to date no clinical and electrophysiological criteria or validated biomarker for the diagnosis of this type of neuropathy. In a retrospective study, we analyzed the files of patients with peripheral sensory neuronopathy certain and established clinical and electrophysiological diagnostic criteria for sensitive neuronopathy. We therefore wish now validate these criteria and investigate possible associated antibodies on a prospective cohort of patients.
Detailed Description
All the patients (patient group and control) will be included in the study after giving their consent. The clinical, biological and electrophysiological data concerning the neuropathy will be collected. There is no specific follow-up for the study. Blood samples will be retrospectively analyzed for antibody screening.
Investigators
Eligibility Criteria
Inclusion Criteria
- •A :Patients Male or female patient aged 18 years or more with a clinically pure sensory neuropathy, abnormal ENMG in sensory nerves in more than one limb and complete etiological assessment allowing a diagnosis of sensory neuronopathy.
- •B :Controls Male or female patient aged 18 years or more with a clinically pure sensory neuropathy, abnormal ENMG in sensory nerves in more than one limb and complete etiological assessment allowing a diagnosis of sensory neuropathy excluding a neuronopathy.
Exclusion Criteria
- •Patient with a sensory-motor neuropathy or incomplete clinical evaluation
Outcomes
Primary Outcomes
Likelihood ratio diagnostic criteria established on the study population
Time Frame: baseline
The set of diagnostic criteria giving the best sensitivity and specificity for a diagnosis of sensory neuronopathy (composite measure)
Secondary Outcomes
- Identified antibodies(baseline)