Investigation of the Effect of Total Knee Arthroplasty on Proinflammatory Cytokine Level, Pain Severity, Functional Status, Joint Position Sense and Radiographic Findings
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 51
- 试验地点
- 2
- 主要终点
- Pain severity
研究概览
简要总结
Knee osteoarthritis is a common disease that causes pain and loss of function. Total Knee Arthroplasty (TKA) is a frequently used surgical method in the treatment of severe knee osteoarthritis. The aim of this study was to investigate the effect of TKA on IL-6, TNF-α and IL-1β cytokine levels, pain intensity at rest and walking, knee joint valgity angle,malaligment, functional status and knee joint position sense.
详细描述
Twenty-nine patients (female/male: 24/5) with grade 4 osteoarthritis were included in the TKA group (study group) and 22 patients (female/male:13/9) with <grade 4 osteoarthritis were included in the control group. Systemic venous blood samples of the patients were taken to evaluate the cytokine level (IL-6, TNF-α, IL-1). The Visual Analogue Scale was used to assess pain intensity, and the WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index) score was used to evaluate the functional status. Valgity and malaligment measurements were calculated using antero-posterior X ray Digital goniometer was used to evaluate the knee joint position sense (at 35, 55 and 70 degrees knee flexion angles). Measurements were taken once from patients in the control group, and twice in pre-op and post-op sixth weeks from study group.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 45 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with grade 4 degeneration levels who had surgical indications between the ages of 45-75 were placed in the study group.
- •Patients without surgical indication, lower than 4 OA severity included in the control group
排除标准
- •Patients with surgical history of the ipsilateral side, neuropathic pain, loss of sensation, systemic, chronic and infectious disease were excluded from the study
结局指标
主要结局
Pain severity
时间窗: 15 minutes
The pain intensity were evaluated by the Visuel Analog Scale.
Valgity angle and amount of malaligment
时间窗: 30 minutes
In this evaluation, the valgity angle and the malalingement amount were calculated on the knee antero-posterior direct X-ray imageby an experienced orthopedist
Functional status
时间窗: 30 minutes
The Western Ontario and McMaster Universities Arthritis Index was used for functional status.
Proinflammatory cytokine level
时间窗: 30 minutes
Systemic venous blood samples were taken. IL-6, TNF-α and IL-1β cytokine levels were examined.
Joint position sense
时间窗: 30 minutes
Electro-goniometer was used for proprioception evaluation
次要结局
未报告次要终点
研究者
Murat EMİRZEOĞLU
Karadeniz Technical University
Karadeniz Technical University