Investigation of the Effect of Total Knee Arthroplasty on Proinflammatory Cytokine Level, Pain Severity, Functional Status, Joint Position Sense and Radiographic Findings
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Orthopedic Disorder
- Sponsor
- Karadeniz Technical University
- Enrollment
- 51
- Locations
- 1
- Primary Endpoint
- Pain severity
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
Knee osteoarthritis is a common disease that causes pain and loss of function. Total Knee Arthroplasty (TKA) is a frequently used surgical method in the treatment of severe knee osteoarthritis. The aim of this study was to investigate the effect of TKA on IL-6, TNF-α and IL-1β cytokine levels, pain intensity at rest and walking, knee joint valgity angle,malaligment, functional status and knee joint position sense.
Detailed Description
Twenty-nine patients (female/male: 24/5) with grade 4 osteoarthritis were included in the TKA group (study group) and 22 patients (female/male:13/9) with \<grade 4 osteoarthritis were included in the control group. Systemic venous blood samples of the patients were taken to evaluate the cytokine level (IL-6, TNF-α, IL-1). The Visual Analogue Scale was used to assess pain intensity, and the WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index) score was used to evaluate the functional status. Valgity and malaligment measurements were calculated using antero-posterior X ray Digital goniometer was used to evaluate the knee joint position sense (at 35, 55 and 70 degrees knee flexion angles). Measurements were taken once from patients in the control group, and twice in pre-op and post-op sixth weeks from study group.
Investigators
Murat EMİRZEOĞLU
Karadeniz Technical University
Karadeniz Technical University
Eligibility Criteria
Inclusion Criteria
- •Patients with grade 4 degeneration levels who had surgical indications between the ages of 45-75 were placed in the study group.
- •Patients without surgical indication, lower than 4 OA severity included in the control group
Exclusion Criteria
- •Patients with surgical history of the ipsilateral side, neuropathic pain, loss of sensation, systemic, chronic and infectious disease were excluded from the study
Outcomes
Primary Outcomes
Pain severity
Time Frame: 15 minutes
The pain intensity were evaluated by the Visuel Analog Scale.
Valgity angle and amount of malaligment
Time Frame: 30 minutes
In this evaluation, the valgity angle and the malalingement amount were calculated on the knee antero-posterior direct X-ray imageby an experienced orthopedist
Functional status
Time Frame: 30 minutes
The Western Ontario and McMaster Universities Arthritis Index was used for functional status.
Proinflammatory cytokine level
Time Frame: 30 minutes
Systemic venous blood samples were taken. IL-6, TNF-α and IL-1β cytokine levels were examined.
Joint position sense
Time Frame: 30 minutes
Electro-goniometer was used for proprioception evaluation