ISRCTN03013488Completed未知
Clinical and cost-effectiveness of total knee replacements versus partial knee replacements for patients with medial compartment osteoarthritis: a multicentre randomised controlled trial
niversity of Oxford (UK)0 sites528 target enrollmentStarted: April 9, 2009Last updated:
Conditions
Trial Snapshot
- Phase
- 未知
- Status
- Completed
- Sponsor
- Enrollment
- 528
Study Overview
Brief Summary
- 2013 protocol in http://www.ncbi.nlm.nih.gov/pubmed/24028414 2. 2017 early results in https://www.arthroscopyjournal.org/article/S0749-8063(17)30895-2/fulltext (added 13/05/2019) 3. 2019 5-year results in https://www.ncbi.nlm.nih.gov/pubmed/31326135 (added 22/07/2019) 4. 2020 results in https://www.ncbi.nlm.nih.gov/pubmed/32369436 (added 06/05/2020)
Study Design
- Study Type
- Interventional
Eligibility Criteria
- Sex
- All
Inclusion Criteria
- •1. Medial osteoarthritis with exposed bone on both femur and tibia or avascular necrosis
- •2. Functionally intact anterior cruciate ligament (superficial damage or splitting is acceptable)
- •3. Full thickness lateral cartilage
- •4. Correctable intra-articular varus deformity (suggestive of functionally intact medical cruciate ligament)
- •5. Medically fit showing an American Society of Anaesthesiologists (ASA) grade 1 or 2
- •6. Expectancy of over 10 years of active life
- •7. Aged 40 years or over, either sex
Exclusion Criteria
- •1. Require revision knee replacement surgery
- •2. Have rheumatoid arthritis or other inflammatory disorders
- •3. Are likely to benefit from a specific prosthesis type
- •4. Are unlikely to be able to perform required clinical assessment tasks
- •5. Have symptomatic foot, hip or spinal pathology
Investigators
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