Fecal microbiota transplantation in severe alcoholic hepatitis- assessment of impact on prognosis and short-term outcome.

PGIMER0 个研究点目标入组 0 人开始时间: 待定最近更新: 2021年11月24日

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•Alcoholic hepatitis, as defined by:
•1. Rapid development or worsening of jaundice and liver-related complications with serum total bilirubin more than 3 milligrams per decilitre.
•2.Aspartate aminotransferase and alanine aminotransferase elevated to more than one and half times the upper limit of normal but less than 400 IU per litre with AST to ALT ratio over 1.5.
•3.Documentation of persistent heavy alcohol use until 8 weeks before onset of symptoms.
•4.Alcohol Consumption in female over 40 grams per day for at least 6 months and in males over 60 grams per day for at least 6 months.
•5.Maddreys Discriminant Function Score of more than 32 OR
•6.A patient of alcoholic hepatitis who will present with grade 1 or 2 of hepatic encephalopathy.

•1. Intestinal paralysis, lack of bowel sounds, intestinal perforation.
•2.Uncontrolled infections.
•3.Uncontrolled upper gastrointestinal bleeding.
•4.Grade 3,4 hepatic encephalopathy.
•5.Hepatic or extrahepatic malignancy.
•6.Maddreyâ??s Discriminant Function (mDF) >90 or MELD >30.
•7.Autoimmune hepatitis, Wilsonâ??s disease, suspected drug induced liver injury.
•8.Patients who are aged >60 years
•9.WBC count <1000 cells/mm3
•10.Pregnancy or nursing.
•11.Human Immunodeficiency Virus (HIV), HBV, HCV infection.
•12.Patientâ??s unwillingness to participate in the study.
•13.Any other condition which, in the opinion of the investigator, would impede compliance or hinder completion of the study.

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