Genetic origin of recurrent hydatidiform moles

• Conditions: molar pregnancy; 10035129

• Registration Number: NL-OMON38464
• Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 30

Inclusion Criteria

objective 1:
- patients with a history of at least two or more hydatidiform moles;objective 2:
- patients from objective 1 without a known mutation in NLRP7 or KHDC3L

Exclusion Criteria

objective 1:
- patients with a history of less than two molar pregnancies;objective 2:
- patients from objective 1 with a mutation in NLRP7 or KHDC3L

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1) To determine the frequency of mutations in NLRP7 or KHDC3L in patients with<br /><br>recurrent hydatidiform moles in the Netherlands.<br /><br>2) To identify additional candidate genes associated with (familial) recurrent<br /><br>HM.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Not applicable.</p><br>