Neurodynamic Interventions for Multiple Sclerosis

Not Applicable

Completed

• Conditions: Multiple Sclerosis
• Interventions: Other: Physical Therapy; Other: Physical Therapy plus Neurodynamic

• Registration Number: NCT03595631
• Lead Sponsor: Universidad Rey Juan Carlos

Brief Summary

A randomized, parallel-group, clinical trial will be conducted to compare the immediate effects of the inclusion of a neurodynamic intervention into a multimodal physiotherapy program on pressure pain sensitivity, pain and manual dexterity in patients with multiple sclerosis

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2018-07-02
• Study First Submitted QC: 2018-07-12
• Study First Posted: 2018-07-23
• Study Start: 2018-07-26
• Primary Completion: 2018-09-15
• Status Verified: 2018-10
• Study Completion: 2018-10-04
• Last Update Submitted: 2018-10-19
• Last Update Posted: 2018-10-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 32

Inclusion Criteria

• a diagnosis of multiple sclerosis according to the modified McDonald criteria;
• symptoms of paresthesia and lack of sensitivity in the upper extremity;
• Expanded Disability Status Scale (EDSS) between 0 and 6.5 points;
• absence of cognitive deficit.

Exclusion Criteria

• any exacerbation of multiple sclerosis during the previous 3 months;
• previous hand surgery or steroid injections treatment in the upper extremity;
• multiple diagnoses on the upper extremity (e.g., cervical radiculopathy);
• cervical, shoulder, or upper extremity trauma;
• other comorbid musculoskeletal medical conditions;
• mini-mental state examination <25

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Physical Therapy	Physical Therapy	Patients will receive 5 session of multimodal physiotherapy treatment of 30min duration including low-load strength exercises, soft tissue mobilization and muscle-tendon stretching exercises twice per week.
Physical Therapy plus neurodynamic	Physical Therapy plus Neurodynamic	Patients will receive 5 session of multimodal physiotherapy treatment of 30min duration including low-load strength exercises, soft tissue mobilization and muscle-tendon stretching exercises twice per week. In addition, they will also receive bilateral nerve slider neurodynamic interventions targeting the median, ulnar and radial nerves.

Primary Outcome Measures

Name	Time	Method
Changes in pressure pain sensitivity	Baseline and one week after the last treatment session	Pressure pain threshold over the median, ulnar and radial nerves, second metacarpal and tibialis anterior

Secondary Outcome Measures

Name	Time	Method
Changes in upper extremity pain intensity before and after the intervention	Baseline and one week after the last treatment session	A Numerical Pain Rate Scale (NPRS, 0-10) will be used to record the mean and the worst intensity of pain in te upper extremity
Changes in light touch detection threshold	Baseline and after treatmentBaseline and one week after the last treatment session	Light touch detection threshold will be assessed with a standardized set of modified twenty von Frey hairs
Changes in manual dexterity	Baseline and one week after the last treatment session	Bilateral manual dexterity was bilaterally assessed using the nine-hole peg test

Trial Locations

Locations (1)

César Fernández-de-las-Peñas; 🇪🇸 Alcorcon, Madrid, Spain