Effects of Neurodynamic Interventions to Multimodal Physical Therapy in Patients With Multiple Sclerosis
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Universidad Rey Juan Carlos
- Enrollment
- 32
- Locations
- 2
- Primary Endpoint
- Changes in pressure pain sensitivity
Study Overview
Brief Summary
A randomized, parallel-group, clinical trial will be conducted to compare the immediate effects of the inclusion of a neurodynamic intervention into a multimodal physiotherapy program on pressure pain sensitivity, pain and manual dexterity in patients with multiple sclerosis
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Triple (Participant, Investigator, Outcomes Assessor)
Eligibility Criteria
- Ages
- 18 Years to 65 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •a diagnosis of multiple sclerosis according to the modified McDonald criteria;
- •symptoms of paresthesia and lack of sensitivity in the upper extremity;
- •Expanded Disability Status Scale (EDSS) between 0 and 6.5 points;
- •absence of cognitive deficit.
Exclusion Criteria
- •any exacerbation of multiple sclerosis during the previous 3 months;
- •previous hand surgery or steroid injections treatment in the upper extremity;
- •multiple diagnoses on the upper extremity (e.g., cervical radiculopathy);
- •cervical, shoulder, or upper extremity trauma;
- •other comorbid musculoskeletal medical conditions;
- •mini-mental state examination <25
Arms & Interventions
Physical Therapy
Patients will receive 5 session of multimodal physiotherapy treatment of 30min duration including low-load strength exercises, soft tissue mobilization and muscle-tendon stretching exercises twice per week.
Intervention: Physical Therapy (Other)
Physical Therapy plus neurodynamic
Patients will receive 5 session of multimodal physiotherapy treatment of 30min duration including low-load strength exercises, soft tissue mobilization and muscle-tendon stretching exercises twice per week. In addition, they will also receive bilateral nerve slider neurodynamic interventions targeting the median, ulnar and radial nerves.
Intervention: Physical Therapy plus Neurodynamic (Other)
Outcomes
Primary Outcomes
Changes in pressure pain sensitivity
Time Frame: Baseline and one week after the last treatment session
Pressure pain threshold over the median, ulnar and radial nerves, second metacarpal and tibialis anterior
Secondary Outcomes
- Changes in upper extremity pain intensity before and after the intervention(Baseline and one week after the last treatment session)
- Changes in light touch detection threshold(Baseline and after treatmentBaseline and one week after the last treatment session)
- Changes in manual dexterity(Baseline and one week after the last treatment session)
Investigators
César Fernández-de-las-Peñas
Director of Department
Universidad Rey Juan Carlos