Urinary Concentration and Diluting Ability in Patients With Chronic Renal Disease and/ or Hypertension

Completed

• Conditions: Renal Insufficiency, Chronic; Hypertension

• Registration Number: NCT00313430
• Lead Sponsor: Erling Bjerregaard Pedersen

Brief Summary

The investigators want to test the hypothesis that patients with chronic renal disease have a poorer ability to preserve water after being thirsty and a poorer ability to excrete water after a load of fluid. They presume that these abilities become poorer when renal insufficiency progresses. The investigators further hypothesize that patients with hypertension also have a decreased ability to concentrate and dilute urine.

Detailed Description

Not available

Study Timeline

• Study Start: 2004-05
• Study First Submitted: 2006-04-11
• Study First Submitted QC: 2006-04-11
• Study First Posted: 2006-04-12
• Primary Completion: 2008-03
• Status Verified: 2015-08
• Last Update Submitted: 2015-08-19
• Last Update Posted: 2015-08-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Patients with chronic renal insufficiency, aged between 18 and 65, both men and women
• Creatinine clearance between 30-59 ml/min
• Patients with hypertension, aged between 18 and 65, both men and women; hypertension is defined as a mean arterial blood pressure in the daytime that is more than 140/90 mm Hg.
• Healthy volunteers, aged between 18 and 65, both men and women

Exclusion Criteria

• Clinical signs or history of disease in the heart, lungs, liver, brain, and endocrine organs
• Cancer
• Alcohol abuse
• Medicine abuse
• Pregnancy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (1)

Department of Medicine, Holstebro Hospital; 🇩🇰 Holstebro, Ringkjoebing, Denmark