Safety and efficacy of azathioprine in the treatment of paradoxical reaction in patients with tuberculous meningitis: A randomized clinical trial - nil

Department of Neurology King George Medical University0 个研究点目标入组 0 人开始时间: 待定最近更新: 2023年12月19日

研究概览

暂无简介。

•All consecutive newly diagnosed patients of tuberculous meningitis, fulfilling the consensus diagnostic criteria as described by Marais et. Al.
•Patients are categorized into definite, probable or possible tuberculous meningitis group on the basis of clinical, imaging and laboratory criteria.
•DEFINITE CASES- either have acid fast bacilli in CSF or mycobacterium could be cultured from CSF or CSF is positive for mycobacterial nucleic acids by PCR.
•PROBABLE CASES- they fulfill the clinical entry criteria plus a total diagnostic score of 10 or more points (when neuroimaging is absent) OR 12 or more points (when neuroimaging is present) plus excision of alternative diagnosis.
•POSSIBLE CASES- clinical entry criteria plus a total diagnostic score of 6-9 points (when neuroimaging is not available) OR 6-11 points (when neuroimaging is available) along with the exclusion of alternative diagnosis.

•1. Patients with cryptococcal meningitis or any other cause for meningitis will be excluded.
•2. Patients with having baseline deranged liver function tests, kidney function tests, pregnancy & lactation will be excluded.
•3. Patients who do not give consent will be excluded.
•4. Age <18 years or >80 years
•5. HIV Positive status

发起方

Department of Neurology King George Medical University