Second Australian National Blood Pressure Study (ANBP2): Effect of Angiotensin-Converting Enzyme (ACE) Inhibitor and Diuretic-based Treatment on rates of cardiovascular-associated mortality in the Elderly

Phase 4

Completed

• Conditions: Hypertension; Cardiovascular - Hypertension

• Registration Number: ACTRN12622000398707
• Lead Sponsor: High Blood Pressure Research Council of Australia

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2006-12-31
• Study Start: 2022-03-08
• Last Update Posted: 14 March 2022

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 6083

Inclusion Criteria

Are 65-84 years of age
- Confirmed hypertension, either untreated or previously treated, with average untreated sitting blood pressure on the 2nd and 3rd screening visits of the study greater than or equal to 160 mmHg or greater than or equal to90 mmHg diastolic (if systolic BP is greater than or equal to 140 mmHg)
- Have no history of recent cardiovascular morbidity (see under exclusion criteria), serious intercurrent illness or a absolute contraindication to an ACE inhibitor or diuretic
- Are capable of and willing to give informed consent
- Are ambulant and able to attend their general practitioner's practise throughout the study

Exclusion Criteria

- Prescence of any previous nonfatal cardiovascular event which defines an end-point for the study in the past 6 months. Refers to any existing condition (eg cancer) which the GP feels is likely to cause death with 5 years.
- Accelerated or malignant hypertension
- Dementia
- Plasma creatinine concentration > 0.2mmol/l. The measurement should have been within the past 12 months or, if this is not available, will be undertaken at the initial screening visit
- Any life threatening illness considered to be likely to cause death within the study's observation period (5 years)
- Presence of any absolute contraindication to or specific indication for an ACE inhibitor or a diuretic
- Consideration by the subject's general practitioner that the subject is unsuitable for the study

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
COMPOSITE PRIMARY OUTCOME : ALL CAUSE mortality and CVD events<br>Data was collected through death record certificates and medical record reviews and links to the national death index[Annually for 5 years post-enrolment]

Secondary Outcome Measures

Name	Time	Method
onfatal cardiovascular events - Source data obtained through GP records, hospital records and death records.[Annually for 5 years post-enrolment]