Exhaled Markers in Asthma during Exacerbations.
Recruiting
- Conditions
- AsthmaExacerbationAstmaExacerbatie
- Registration Number
- NL-OMON26310
- Lead Sponsor
- Academic Medical Centre, University of Amsterdam.
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 30
Inclusion Criteria
1. Age >18 years;
2. Mild to moderately severe persistent asthma according to the criteria GINA [2]:
Exclusion Criteria
1. Change in the dose of ICS within 4 weeks prior to screening;
2. A course of oral corticosteroids, antibiotics or a respiratory infection within 4 weeks prior
to the study;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Breathprints of volatile organic compounds which are associated with loss of asthma control (deterioration in symptoms and lung function) after interruption of inhaled steroid therapy.
- Secondary Outcome Measures
Name Time Method 1. The critical VOCs of these breathprints in exhaled air by gas chromatography<br>and mass spectrometry (GC-MS);<br /><br>2. The individual biomarkers in sputum, blood and EBC that are associated with<br>asthma control and electronic nose and GC-MS breathprints;<br /><br>3. The effect of loss of asthma control by interruption of inhaled steroids on<br>haemostatic activity;<br /><br>4. The association between markers of coagulation, inflammation and exhaled molecular profiles assessed by electronic nose and GC-MS.