Body mass index and microcirculatory behavior in patients undergoing cardiac surgery with cardiopulmonary bypass

Recruiting

• Conditions: Perioperatieve complicaties in de doorbloeding van organen; disturbances in perfusion of tissues during surgery; Perioperative disturances in tissue perfusion; 10007593

• Registration Number: NL-OMON47560
• Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 70

Inclusion Criteria

* (non-aortic) cardiac surgery
* Adult subjects
* Informed consent
* BMI * 32 kg/m2 or BMI < 25 kg/m2.

Exclusion Criteria

* Re-operation
* Aortic surgery
* Emergency operation
* Diabetes mellitus type I and II

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary endpoint is the difference in perfused vessel density before<br /><br>surgery and immediately after weaning from cardiopulmonary bypass. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>* Patient demographics<br /><br>* Proportion of perfused vessels (PPV)<br /><br>* Perfused vessel density (PVD)<br /><br>* Microvascular flow index (MFI)<br /><br>* Perfused boundary region<br /><br>* Mean arterial pressure<br /><br>* Glucose levels<br /><br>* Metabolic parameters (pH, lactate, base excess, pCO2, HCO3)<br /><br>* Glycocalyx markers (heparan sulphate, syndecan)<br /><br>* Postoperative complications (ICU stay > 24 hours, mechanical ventilation > 24<br /><br>hours, pneumonia, CVA/TIA, myocardial infarction, atrial fibrillation), 30-day<br /><br>mortality</p><br>